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Introduction. Extramural venous invasion (EMVI) is a significant predictive factor of the prognosis for patients with colorectal carcinoma and it is directly connected with the relapse of a disease, especially with the appearance of distant metastases. Methods. The research comprises 90 patients with colorectal cancer. Representative samples of tum...

By Mirjana Ćuk, Slavica Knežević Ušaj, Ištvan Klem, Radoslav Gajanin, Danijela Batinić Škipina, Radmil Marić, Sanja Marić, Nenad Lalović, Nikolina Dukić

Introduction. The Bcl-2 gene codes an oncoprotein, inhibits a programmed cell death or apoptosis and it plays a very important role in colorectal cancerogenesis. The aim of our study is to determine Bcl-2 expression in colorectal carcinomas in relation with the stage of disease, histology of tumor type, localization and macroscopic growth pattern. ...

By Danijela Batinić Škipina, Slavica Knežević Ušaj, Dragana Zec, Mirjana Ćuk, Snežana Božanić, Nenad Lalović

Holistic approach to the nature of human beings shows the view of the man as a unique and indivisible whole and not as a collection of organs that are not interconnected. This means the integrity of the biological, psychological and social nature of the man and that just means the psychosomatic approach to the disease. More and more studies indicat...

By Snežana Medenica, Milan Stojaković, Bogdan Zrnić, Goran Vasić, Verica Prodanović, Helena Marić

Skin lesions have a strong influence on the mental health. Literature indicates the complex interrelationships between psychosocial factors and psoriasis, which substantially reduce the quality of life of these patients. These interrelationships are based on numerous interactions that exist between the immune, nervous and endocrine systems and they...

By Bogdan Zrnić, Snežana Medenica, Aleksandra Salamadić, Zoran Pantić, Siniša Ristić