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30.06.2022.

Original Scientific Articles

Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

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Edited by:

Prof. Siniša Ristić MD, PhD

Vol 14, No 2 (2023):

Biomedicinska istraživanja

Published: 29.12.2023.

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31.05.2024. Reviews Online First
Treatment approaches of central auditory processing deficit

By Sladjana Calasan, Sofija Bajagić, Branislava Ćurčić

Central auditory processing disorder (CAPD) disrupts the brain ability to interpret sound signals despite normal peripheral hearing function. This article aims to identify and analyze various treatment approaches, which are used in the treatment of CAPD and to provide an overview of available empirical evidence on the effectiveness of these approaches. Google Scholar, PubMed and Research Gate were used for literature review. Treatment approaches vary and depend on the individual characteristics of children themselves, and one of the most commonly used approaches in the treatment is auditory training, through which children learn to identify and discriminate auditory stimuli. Apart from choosing the appropriate approach, it is crucial to commence the treatment of children with central auditory processing deficit in time in order to overcome and eliminate this deficit. 

16.04.2024. Original Scientific Articles Online First
Two-tiered serology in patients with Lyme neuroborreliosis

By Tatjana Roganović, Miloš Korać, Borut Bosančić, Višnja Mrdjen, Ljiljana Božić, Andjela Bojanić

Introduction. Lyme borreliosis is a multisystem infectious disease caused by Borrelia burgdorferi sensu lato complex. It is transmitted by Ixodes ticks. Apart from erythema migrans, other manifestations require laboratory confirmation. The aim of our study was to analyze the results of Two-Tiered Testing in patients with possible Lyme neuroborreliosis (LNB).

Method. We conducted a prospective diagnostic study at the University Clinical Centre of Republic of Srpska from October 2017 to October 2021. The study included 51 patients exam ined and treated under suspicion of Lyme neuroborreliosis (LNB). We used Two-Tiered Testing through ELISA anti-Borrelia IgM/IgG and confirmatory Immunoblot anti-Borrelia test IgM/ IgG.

Results. ELISA anti-Borrelia IgM in serum was positive in 25.5% patients and IgG in 76.47%, while in cerebrospinal fluid (CSF) IgM was positive in 13.7% patients and IgG in 39.2%. Immuno blot test of anti-Borrelia IgM in serum was at the borderline in 7.84% patients, positive in 6.17% and no data for 35.29%, while IgG was positive in 54.9% of patients and no data for 37.25%. A strong correlation between results of ELISA anti-Borrelia IgM in serum and CSF was observed (ρ=0.802, p<0.001) and also between ELISA anti-Borrelia IgG and Immunoblot IgG in serum (ρ=0.787, p<0.001).

Conclusion. Two-Tiered Testing is very important in patients with possible LNB. False positive and false negative results are possible and test should be interpreted with caution and in correlation with the clinical manifestation and other avail able tests. More work needs to be done to develop new reli able diagnostic test for LNB, such as detection of CXCL13 in CSF, titrate the interleukin-6 (IL-6) in addition to the CXCL13 chemokine.

15.04.2024. Original Scientific Articles Online First
Preeclampsia and Preterm Delivery Risk: The Significance of Obesity in Pregnancy

By Tamara Perić, Mirjana Bogavac, Zoran Belopavlović

Central auditory processing disorder (CAPD) disrupts the brain ability to interpret sound signals despite normal peripheral hearing function. This article aims to identify and analyze various treatment approaches, which are used in the treatment of CAPD and to provide an overview of available empirical evidence on the effectiveness of these approaches. Google Scholar, PubMed and Research Gate were used for literature review. Treatment approaches vary and depend on the individual characteristics of children themselves, and one of the most commonly used approaches in the treatment is auditory training, through which children learn to identify and discriminate auditory stimuli. Apart from choosing the appropriate approach, it is crucial to commence the treatment of children with central auditory processing deficit in time in order to overcome and eliminate this deficit. 

27.03.2024. Original Scientific Articles Online First
A STUDY OF THE INCIDENCE AND FACTORS ASSOCIATED WITH GLIOBLASTOMA MULTIFORME IN THE REPUBLIC OF SRPSKA

By Nataša Janjić, Slađana Vranješ

27.03.2024. Original Scientific Articles Online First
Cytotoxicity and anti-inflammatory properties of a GLP-1 receptor agonist in a model of human peripheral blood mononuclear cell culture

By Marija Drakul, Vanja Mališ, Sara Rakočević, Ljiljana Kozić, Darinka Popović, Anđela Mandić, Miodrag Colic

19.03.2024. Case Reports Online First
Gemination of maxillary incisors in decidous and permanent dentition – a case report

By Isidora Nešković, Aleksandar Anđelković, Duška Blagojević, Sanja Vujkov, Jelena Komšić, Bojan Petrović

16.05.2023. Original Scientific Articles Online First
INFLUENCE OF AGING AND LIMB DOMINANCE ON REFERENCE VALUES OF MEDIAN AND ULNAR NERVE CONDUCTION STUDIES

By Igor Sladojević, Tatjana Bućma, Milkica Glogovac Kosanović, Branislava Ćurčić

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

Current issue
07.11.2023. Original Scientific Articles
Knowledge and attitudes of employees at the Faculty of Medicine Foča about the concept and ethical issues in genetics

By Nikolina Elez-Burnjaković, Milena Dubravac Tanasković, Milan Kulić, Radmila Balaban Đurević, Aleksandar Tanović, Kristina Drašković Mališ, Biljana Vasiljević, Bojan Joksimović

14.11.2023. Original Scientific Articles
Methodological pluralism or multimethod research in health and medical sciences

By Srdjan Živanović, Jelena Pavlović, Natalija Hadživuković, Sandra Matović, Olivera Kalajdžić, Bojana Vuković, Ljubiša Kucurski

20.11.2023. Original Scientific Articles
Risk factors for the emergence of frailty in elderly persons in Bosnia and Herzegovina

By Natalija Hadživuković, Jelena Pavlović, Srdjan Živanović, Sandra Matović, Srdjan Mašić, Dragan Spaić, Olivera Kalajdžić, Ljubiša Kucurski, Mile Despotović

12.01.2023. Original Scientific Articles
Sports activities and psychophysical health of deaf and hard of hearing people

By Jasmina Karić B., Milena Kordić B., Vladimir Živanović R., Jana Mitrić, Siniša Šolaja, Ilija Stijepić

18.12.2023. Original Scientific Articles
Sex-dependent differences in patients treated with regular hemodialysis

By Ljubica Mitev Prokopović, Miodrag Sokolović, Branimir Haviža Lilić, Miomir Prokopović

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01.12.2011. Original Scientific Articles
Dijagnostika fokalnih promjena u jetri

By Zoran Terzić, Branko Brmbolić, Miloš Korać, Boban Đorđević, Dragica Terzić, Bogdanka Andrić, Siniša Ristić

Uvod. Patološki procesi u jetri mogu biti difuznog karaktera (zapaljenski,metaboličke bolesti, hematološke bolesti, toksične bolesti) i fokalne (zapaljenske,parazitarne i tumorske). Cilj rada je prikaz fokalnih promjena u jetrinomparenhimu nakon ultrazvučne, laparaskopske i patohistološke dijagnostike.Metode. Retrospektivno-prospektivnim ispitivanjem je obuhvaćeno 147punoljetnih pacijenata oba pola. Fokalne promjene jetrinog tkiva su sagledaneultrazvučnom, laparoskopskom i patohistološkom dijagnostikom.Rezultati. Osnovne karakteristike ispitanika: muškaraca 71 i žena 76 sanajvećim brojem pacijenata (102 - 70%) životne dobi između 40 i 70 godina,sa ravnomjernom distribucijom za svakih deset godina starosti. Međutim,neobično je veliki broj pacijenata ženskog pola registrovan u četvrtoj decenijiživota, čak 14 (9,5%) od ukupnog broja ispitanika, odnosno 18% odispitanika ženskog pola. Metastaze čine 104 (71%) svih fokalnih lezija jetre.U većini slučajeva radilo se o metastazama karcinoma dojke. Iako najčešćeimaju tipičnu ultrazvučnu prezentaciju, metastaze u jetri mogu da daju širokspektar različitih ultrazvučnih slikaZaključak. Najčešće fokalne promjene u jetri su metastaze adenokarcinoma.Samo 3 (2%) fokalne promjene dijagnostikovane ultrazvukom nisu potvrđenekao fokalne laparoskopskom tehnikom i patohistološkom analizom tkiva jetre.

30.06.2022. Original Scientific Articles
Voice condition assessment and the effect of rehabilitation in vocal professionals

By Mila Bunijevac, Zlatko Maksimović, Andrijana Mikić

28.06.2021. Reviews
Vitamin D and atherosclerosis

By Olivera Rašević, Maida Mulić, Maja Vuković, Vesna Lazić, Biljana Mijović, Miloš Maksimović

28.06.2021. Original Scientific Articles
The knowledge of nurses about prevention of infections caused by the bacteria Clostridium difficile

By Ivana Miljković, Amajla Topuz

01.12.2012. Original Scientific Articles
Sensibility of tactile discrimination between the fingers of the dominant and non-dominant hands

By Olivera P Spasojević, Zoran Obradović, Slavko Grbić, Marinko Domuzin, Aleksandra Grbić

Introduction. Uninjured fingers of the opposite hand are often used to control the recovery of sensibility in injured fingertips. The aim of this study is to examine the sensitivity of the surface on the fingertips between the dominant and non-dominant hand using static and dynamic two-point discrimination test and determine if there are significant differences in sensibility between the fingers of the dominant and
non-dominant hands.

Methods
. The research was done on 50 persons (500 fingers) using two-point test for measuring tactile discrimination of fingers (two-point discrimination test - 2PD). 2PD test is the most widely used test for the control of sensory recovery after nerve injury. Dynamic and static two-point discrimination method was used.
Results
. Using the static two-point discrimination test, we found out that the highest sensibility was in the index finger in both the dominant and non-dominant hand (dominant, 2.78 ± 0.78 mm, non-dominant, 2.82 ± 0.75 mm) and the lowest sensitivity of the little finger (dominant: 3.18 ± 0.88 mm, non-dominant:
3.01 ± 0.71 mm). Using the dynamic discrimination test, we found out that the most sensitivity was of
the index finger (dominant, 2.44 ± 0.71 mm, non-dominant, 2.42 ± 0.52 mm) and the lowest of the little finger (dominant, 2.67 ± 0.88 mm, non-dominant, 2.66 ± 0.71 mm). Overall, using t-test at the significance level of p = 0.05, there was no significant difference in the sensitivity of the fingers in pairs between the dominant and non-dominant hand.
Conclusion
. The difference in sensitivity was not statistically significant between pairs of fingers and toes of the surveyed sensibility between the dominant and non-dominant hand (p> 0.05). Therefore, in order to monitor the recovery of sensibility, the sensibility of injured fingertips can be compared with the sensibility in fingers of opposite healthy hand.

30.06.2022. Original Scientific Articles
Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

28.06.2012. Original Scientific Articles
Učešće medicinskih sestara u rješavanju akutnih komplikacija dijabetesa

By Mirjana Stamenović, Ljiljana Milović, Natalija Hadživuković, Jelena Pavlović, Sandra Joković

28.12.2020. Reviews
Importance of documentation in nursing practice

By Amajla Topuz, Ivana Miljković

Nursing is an established discipline that helps people in having a productive and healthy life as well as in coping with health problems in the best possible way using established skills. The application of nursing interventions and measures based on the analysis and assessment of patient needs, problems and difficulties observed, and his or her abilities as well as on a continuous assessment and verification of the results obtained is carried out by means of the healthcare process. The rational and logical basis for defining and solving patient's problems is within the scope of healthcare process. Professional networking as well as the networking of all hierarchical structures is a priority where the filing of nursing documentation in a centralized information system is concerned. Nursing documentation is used to establish effective communication between non-medical and medical staff, between nurses and, between families, as well as to establish effective communication with the healthcare system during the overall patient care process.

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