×
Home Current Archive Editorial board
News Contact

30.06.2022.

Original Scientific Articles

Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

Read the full article

Publishing collaboration

info

Edited by:

Prof. Siniša Ristić MD, PhD

Vol 15, No 2 (2024):

Biomedicinska istraživanja

Published: 18.12.2024.

See all
19.05.2025. Original Scientific Articles Online First
Production of chemokines by mesenchymal stromal cells established from inflamed human gingiva and its modulation by lipopolysaccharide

By Marina Radanović, Miodrag Čolić

Introduction. The role of gingiva-derived stromal cells (GMSCs) in chronic periodontitis is poorly understood. Since GMSCs modulate the inflammatory and immune responses this study aimed to investigate the production of chemokines by GMSCs established from chronic periodontitis tissue under basal conditions and after stimulation with lipopolysaccharide (LPS), which is a main trigger of gingivitis/periodontitis. 
Methods. GMSCs, established from periodontitis-affected gingival tissue, were characterized by flow cytometry and their differentiation capability. GMSCs, from the 5th passage, were cultivated either alone or with LPS for 24 hours followed by the determination of chemokine levels in culture supernatants by a sandwich ELISA assay. 
Results. More than 95% of GMSCs expressed all three (CD90, CD73, and CD105) MSC markers, with a relatively high potential to differentiate into osteoblasts and chondroblasts and a low adipogenic differentiation capability. Of all chemokines, the basal production of interleukin-8 (IL-8) (186.2 ± 23.4 pg/mL) and Monocyte Chemoattractant Protein-1 (MCP-1) (103.5 ± 12.7 pg/mL) was highest, followed by the levels of  Growth-Related Oncogene (GRO)-α (16.2 ± 
2.4 pg/mL) and Regulated Upon Activation, Normal T-cell Expressed and Secreted (RANTES) (10.3 ± 1.4 pg/mL ). The basal production of Interferon (IFN)-γ-Induced Protein 10 kDa (IP-10) was undetectable. When stimulated with LPS, GMSCs significantly up-regulated the production of all chemokines. Their levels (pg/mL) were as follows: IL-8 – 926.4 ± 84.0; MCP-1 – 424.0 ± 33.2; GRO-α – 109.3 ± 12.2; RANTES – 154.9 ± 6.6; IP-10 – 211.6 ± 15.7. 
Conclusion. GMSCs may promote or suppress periodontal inflammation depending on produced chemokines and their balance.

19.05.2025. Original Scientific Articles Online First
Application of hyperthermic intraperitoneal chemotherapy at the University Clinical Center of Republic of Srpska

By Zoran G. Aleksić, Dragan Tomić, Velimir Škrbić, Nenad Jaćimović, Miroslav Popović, Sladibor Lakić

Introduction. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is an advanced treatment modality for peritoneal malignancies, including ovarian cancer, appendix adenocarcinoma, colorectal cancer, and peritoneal metastases. This approach offers potential benefits in managing these complex conditions.
Methods. The effectiveness of CRS with HIPEC depends on the selection of cytostatics, their pharmacokinetics, and pharmacodynamics. Although these complex surgical procedures are associated with certain risks, they typically result in fewer complications and shorter hospital stays.
Results. The first CRS-HIPEC procedure at the University Clinical Center of Republic of Srpska was conducted on February 26, 2020. From February 2020 to February 2023, 42 CRS-HIPEC procedures were performed with favorable postoperative outcomes. The treatment led to a lower incidence of intraoperative (0%) and postoperative complications (11.9% in five patients), reduced side effects of local chemotherapy compared to systemic chemotherapy, and a decrease in mortality rates (2.4% in one patient). The patients were aged between 40 and 70 years. A multidisciplinary team of surgeons, gynecologists, anesthesiologists, oncologists, and perfusionists carried out the procedures.
Conclusion. Local intraoperative chemotherapy through HIPEC represents a modern and effective treatment approach that improves both surgical and oncological outcomes. Our institution and the Clinic for General and Abdominal Surgery should continue to adopt innovative procedures to enhance treatment and patient care.

16.04.2025. Original Scientific Articles Online First
Predictive influence of sociodemographic characteristics and the type of developmental disorder on children’s adaptive achievements

By Sladjana Ćalasan, Nadica Jovanović-Simić, Bojana Drljan

Introduction. Adaptive behavior, which includes conceptual, social, and practical skills, is a key indicator of children’s dai
ly functioning. Its assessment is particularly important in identifying intellectual disabilities, as well as in evaluating the developmental potential of children with various developmental disorders and those with typical development. The aim of this study was to examine the predictive power of sociodemographic factors and type of develop
mental disorder in relation to children’s adaptive achievements.
Methods. The study was conducted on a sample of 183 children, aged 4 to 14 years, divided into four groups: children with developmental language disorder (DLD), autism spectrum disorder (ASD), mild intellectual disability (MID), and typically developing children (TD). Data were collected using a specially designed questionnaire and the Adaptive Behavior Diagnostic Scale (ABDS).
Results. Regression analysis showed that the type of developmental disorder was the strongest predictor of adaptive functioning across all examined domains. The number of siblings was also a significant predictor of the overall adaptive score and most individual domains, except the social domain. Family income emerged as the significant 
predictor in the conceptual domain.
Conclusion. The type of developmental disorder has a dominant influence on children’s adaptive achievements, while certain sociodemographic variables additionally contribute to explaining variations in adaptive behavior. These findings highlight the need for an individualized approach in assessment and intervention planning.

15.04.2025. Original Scientific Articles Online First
Neuropathic pain in diabetic peripheral neuropathy and chronic low back pain syndrome: prevalence and characteristics

By Zoran Vukojević, Aleksandra Dominović Kovačević, Sanja Grgić, Daliborka Tadić, Srdjan Mavija

06.02.2025. Original Scientific Articles Online First
The role of voice-related quality of life (V-RQOL) questionnaire in assessing quality of life in patients with vocal fold paralysis

By Mirjana Gnjatić, Dalibor Vranješ, Daliborka Tadić, Zorica Novaković

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

Current issue
18.09.2024. Reviews
Possibilities of violation of ethical principles in sponsored research: analysis, consequences, and prevention measures

By Jovan Kulić, Dragana Aksentijević, Ana Kostović, Dejan Krstić, Dragana Branović, Bojan Joksimović, Marija Milić, Stefan Mitić, Siniša Ristić

18.09.2024. Reviews
Anatomy of the vertebral vein

By Slobodan Malobabić

18.09.2024. Original Scientific Articles
Assessment of mental health disorders in individuals with chronic diseases during the COVID-19 pandemic

By Danijela Radulović, Srdjan Mašić, Dejan Bokonjić, Svetlana Radević, Ivana Simić Vukomanović, Biljana Mijović, Maja Vuković, Milena Dubravac Tanasković, Mirka Jojić, Jelena Vladičić Mašić, Dragan Spaić

18.09.2024. Original Scientific Articles
The effect of socio-demographic characteristics on the burnout syndrome of nurses in Republic of Srpska during the COVID-19 pandemic

By Ljubiša Kucurski, Tamara Popović, Dijana Djurić, Jelena Pavlović, Ljiljana Savić, Srdjan Živanović, Ljubinka Božić Majstorović, Sanja Tomić

18.09.2024. Original Scientific Articles
Stress in parents of children with developmental disabilities

By Andrijana Bakoč, Olivera Kalajdžić, Ranka Perućica, Ivana Zečević

Recent issues
See all
Most read
See all
01.12.2011. Original Scientific Articles
Dijagnostika fokalnih promjena u jetri

By Zoran Terzić, Branko Brmbolić, Miloš Korać, Boban Đorđević, Dragica Terzić, Bogdanka Andrić, Siniša Ristić

Uvod. Patološki procesi u jetri mogu biti difuznog karaktera (zapaljenski,metaboličke bolesti, hematološke bolesti, toksične bolesti) i fokalne (zapaljenske,parazitarne i tumorske). Cilj rada je prikaz fokalnih promjena u jetrinomparenhimu nakon ultrazvučne, laparaskopske i patohistološke dijagnostike.Metode. Retrospektivno-prospektivnim ispitivanjem je obuhvaćeno 147punoljetnih pacijenata oba pola. Fokalne promjene jetrinog tkiva su sagledaneultrazvučnom, laparoskopskom i patohistološkom dijagnostikom.Rezultati. Osnovne karakteristike ispitanika: muškaraca 71 i žena 76 sanajvećim brojem pacijenata (102 - 70%) životne dobi između 40 i 70 godina,sa ravnomjernom distribucijom za svakih deset godina starosti. Međutim,neobično je veliki broj pacijenata ženskog pola registrovan u četvrtoj decenijiživota, čak 14 (9,5%) od ukupnog broja ispitanika, odnosno 18% odispitanika ženskog pola. Metastaze čine 104 (71%) svih fokalnih lezija jetre.U većini slučajeva radilo se o metastazama karcinoma dojke. Iako najčešćeimaju tipičnu ultrazvučnu prezentaciju, metastaze u jetri mogu da daju širokspektar različitih ultrazvučnih slikaZaključak. Najčešće fokalne promjene u jetri su metastaze adenokarcinoma.Samo 3 (2%) fokalne promjene dijagnostikovane ultrazvukom nisu potvrđenekao fokalne laparoskopskom tehnikom i patohistološkom analizom tkiva jetre.

30.06.2022. Original Scientific Articles
Voice condition assessment and the effect of rehabilitation in vocal professionals

By Mila Bunijevac, Zlatko Maksimović, Andrijana Mikić

01.12.2012. Original Scientific Articles
Sensibility of tactile discrimination between the fingers of the dominant and non-dominant hands

By Olivera P Spasojević, Zoran Obradović, Slavko Grbić, Marinko Domuzin, Aleksandra Grbić

28.06.2021. Reviews
Vitamin D and atherosclerosis

By Olivera Rašević, Maida Mulić, Maja Vuković, Vesna Lazić, Biljana Mijović, Miloš Maksimović

28.06.2021. Original Scientific Articles
The knowledge of nurses about prevention of infections caused by the bacteria Clostridium difficile

By Ivana Miljković, Amajla Topuz

Introduction. Clostridium difficile is the leading cause of nosocomial diarrhea, associated with the use of antibiotics. The most common ways of transmitting the infection in hospitals are contaminated surfaces of the premises and the hands of medical staff. Methods. The study involved 68 nurses/technicians employed at the University Hospital Foca in the departments of surgery and internal medicine. As a research instrument, we used a specially designed questionnaire, created by the authors for the purpose of this research. Results. The research showed that 61.8% of respondents knew that hand washing with warm water and soap was considered the most effective prevention of the spread of infections, and 55.88% meant that they used chlorine-based preparations and hydrogen peroxide as the only effective disinfectant. Nurses with a work experience of less than 5 years showed better knowledge than other groups. Conclusion. The knowledge of nurses about the prevention of C. difficile infection is not at a satisfactory level, which indicates the growing need for education of nurses.

30.06.2022. Original Scientific Articles
Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

28.12.2020. Reviews
Importance of documentation in nursing practice

By Amajla Topuz, Ivana Miljković

01.12.2015. Case Reports
Faktori koji utiču na ishod liječenja sindroma kaude ekvine

By Zorislava Bajić, Milada Nalesnik, Tatjana Boškić, Biljana Jovanović, Tatjana Bućma

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

Partners