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30.06.2022.

Original Scientific Articles

Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

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Edited by:

Prof. Siniša Ristić MD, PhD

Vol 14, No 2 (2023):

Biomedicinska istraživanja

Published: 29.12.2023.

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28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

27.03.2024. Original Scientific Articles Online First
A STUDY OF THE INCIDENCE AND FACTORS ASSOCIATED WITH GLIOBLASTOMA MULTIFORME IN THE REPUBLIC OF SRPSKA

By Nataša Janjić, Slađana Vranješ

Introduction. Glioblastoma multiforme (GBM) is a highly aggressive brain or spinal cord tumor, representing the most lethal form of brain tumors with a five-year mortality rate exceeding 90%. It constitutes ap proximately 60% of all primary brain tumors in adults and has an annual incidence of 2–3 new cases per 100,000 population. Although it pre dominantly affects adult patients, it can occur at any age. The aim of this study is to determine the incidence rate and factors (age, sex and out come) associated with GBM in Republic of Srpska over a five-year period.

Methods. This retrospective observational cross-sectional study includ ed a total of 97 male and female patients of all age groups from the terri tory of Republic of Srpska, who were pathohistologically diagnosed with GBM between January 1st, 2014 and December 31st, 2018. Data obtained from the National Registry for Malignant Neoplasms in Republic of Srps ka, managed by the Public Health Institute and the Republic Institute of Statistics, were analyzed using Microsoft Excel. Results. During the investigated period, GBM accounted for 15.13% of all reported brain tumors in Republic of Srpska with incidence rate of 8.45 per 100,000 population. The occurrence of this tumor was slightly higher in males, with a ratio of 1.2:1.0 compared to females. No cases were reported in patients under the age of 18. Among the reported cas es, 65 persons (67.01%) were between 18 and 65, with incidence rate of 5.66 per 100,000 population, while 32 persons (32.99%) were over 65, with incidence rate of 2,78 per 100,000 population. Out of all patients diagnosed with GBM, 80 patients (82.47%) experienced a fatal outcome, while 17 patients (17.53%) survived.

Conclusion. GBM exhibits a high incidence compared to other brain neoplasms within Republic of Srpska, and it is characterized by an ex tremely high mortality rate, primarily affecting adult, working-age pop ulation (18–65 years).

 

27.03.2024. Original Scientific Articles Online First
Cytotoxicity and anti-inflammatory properties of a GLP-1 receptor agonist in a model of human peripheral blood mononuclear cell culture

By Marija Drakul, Vanja Mališ, Sara Rakočević, Ljiljana Kozić, Darinka Popović, Anđela Mandić, Miodrag Colic

Introduction. GLP-1R agonists (GLP-1RAs) are a type of anti-hyperglycemic medications used for the management of type 2 diabetes mellitus (T2DM). In addition to glucose-lowering effects, GLP-1R agonists (GLP-1RAs) also provide further advantages by promoting weight loss and controlling blood pressure. Furthermore, GLP-1RAs have been reported for their therapeutic benefits in neurological, cardiovascular, endocrine, and metabolic diseases. Emerging evidence from many clinical and experimental studies, as well as in vitro researches, suggests that GLP-1RA agonists may reduce inflamma tion and modify the immunological response, but the underlying molecu lar mechanisms remain unclear. In this research, we examined the effect of GLP-1RA on the cytotoxicity, proliferative activity, and cytokine production of human peripheral blood mononuclear cells (PBMCs) in vitro.

Methods. The peripheral blood mononuclear cells (PBMCs) cultures from healthy volunteers were used. GLP-1RA (DMB), in different concentrations, was added to the cell cultures. A flow cytometry assay was used to assess cell viability, while MTT and CFSE dye dilution assays were used to quantify proliferative activity. Cytokine levels were measured using a sandwich en zyme-linked immunosorbent assay (ELISA).

Results. The cytotoxicity data demonstrated that only the highest DMB concentration (1000 nM) decreased the metabolic activity (viability) of PBMCs (p<0.05) in comparison to untreated cultures, while concentra tions of 200 nM (p<0.05) and 1000 nM (p<0.001) of GLP-1RA increased the proportion of late apoptotic and necrotic cells (p<0.001). The prolif eration of PBMCs was significantly decreased in the presence of GLP-1RA at a 100 nM concentration when compared to the control (p<0.05). The same concentration of GLP-1RA significantly reduced the production of IL-6, IL-1β, and TNF-α.

Conclusion. Our results suggested that GLP-1RA (DMB), at a non-toxic concentration of 100 nM, inhibited the proliferation and production of pro-inflammatory cytokines by human PBMCs in vitro. These findings open the perspective to study the immune response in detail in future experiments.

19.03.2024. Case Reports Online First
Gemination of maxillary incisors in decidous and permanent dentition – a case report

By Isidora Nešković, Aleksandar Anđelković, Duška Blagojević, Sanja Vujkov, Jelena Komšić, Bojan Petrović

Introduction. Glioblastoma multiforme (GBM) is a highly aggressive brain or spinal cord tumor, representing the most lethal form of brain tumors with a five-year mortality rate exceeding 90%. It constitutes ap proximately 60% of all primary brain tumors in adults and has an annual incidence of 2–3 new cases per 100,000 population. Although it pre dominantly affects adult patients, it can occur at any age. The aim of this study is to determine the incidence rate and factors (age, sex and out come) associated with GBM in Republic of Srpska over a five-year period.

Methods. This retrospective observational cross-sectional study includ ed a total of 97 male and female patients of all age groups from the terri tory of Republic of Srpska, who were pathohistologically diagnosed with GBM between January 1st, 2014 and December 31st, 2018. Data obtained from the National Registry for Malignant Neoplasms in Republic of Srps ka, managed by the Public Health Institute and the Republic Institute of Statistics, were analyzed using Microsoft Excel. Results. During the investigated period, GBM accounted for 15.13% of all reported brain tumors in Republic of Srpska with incidence rate of 8.45 per 100,000 population. The occurrence of this tumor was slightly higher in males, with a ratio of 1.2:1.0 compared to females. No cases were reported in patients under the age of 18. Among the reported cas es, 65 persons (67.01%) were between 18 and 65, with incidence rate of 5.66 per 100,000 population, while 32 persons (32.99%) were over 65, with incidence rate of 2,78 per 100,000 population. Out of all patients diagnosed with GBM, 80 patients (82.47%) experienced a fatal outcome, while 17 patients (17.53%) survived.

Conclusion. GBM exhibits a high incidence compared to other brain neoplasms within Republic of Srpska, and it is characterized by an ex tremely high mortality rate, primarily affecting adult, working-age pop ulation (18–65 years).

 

Current issue
07.11.2023. Original Scientific Articles
Knowledge and attitudes of employees at the Faculty of Medicine Foča about the concept and ethical issues in genetics

By Nikolina Elez-Burnjaković, Milena Dubravac Tanasković, Milan Kulić, Radmila Balaban Đurević, Aleksandar Tanović, Kristina Drašković Mališ, Biljana Vasiljević, Bojan Joksimović

18.12.2023. Original Scientific Articles
Sex-dependent differences in patients treated with regular hemodialysis

By Ljubica Mitev Prokopović, Miodrag Sokolović, Branimir Haviža Lilić, Miomir Prokopović

20.11.2023. Original Scientific Articles
Risk factors for the emergence of frailty in elderly persons in Bosnia and Herzegovina

By Natalija Hadživuković, Jelena Pavlović, Srdjan Živanović, Sandra Matović, Srdjan Mašić, Dragan Spaić, Olivera Kalajdžić, Ljubiša Kucurski, Mile Despotović

14.11.2023. Original Scientific Articles
Methodological pluralism or multimethod research in health and medical sciences

By Srdjan Živanović, Jelena Pavlović, Natalija Hadživuković, Sandra Matović, Olivera Kalajdžić, Bojana Vuković, Ljubiša Kucurski

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01.12.2011. Original Scientific Articles
Dijagnostika fokalnih promjena u jetri

By Zoran Terzić, Branko Brmbolić, Miloš Korać, Boban Đorđević, Dragica Terzić, Bogdanka Andrić, Siniša Ristić

Uvod. Patološki procesi u jetri mogu biti difuznog karaktera (zapaljenski,metaboličke bolesti, hematološke bolesti, toksične bolesti) i fokalne (zapaljenske,parazitarne i tumorske). Cilj rada je prikaz fokalnih promjena u jetrinomparenhimu nakon ultrazvučne, laparaskopske i patohistološke dijagnostike.Metode. Retrospektivno-prospektivnim ispitivanjem je obuhvaćeno 147punoljetnih pacijenata oba pola. Fokalne promjene jetrinog tkiva su sagledaneultrazvučnom, laparoskopskom i patohistološkom dijagnostikom.Rezultati. Osnovne karakteristike ispitanika: muškaraca 71 i žena 76 sanajvećim brojem pacijenata (102 - 70%) životne dobi između 40 i 70 godina,sa ravnomjernom distribucijom za svakih deset godina starosti. Međutim,neobično je veliki broj pacijenata ženskog pola registrovan u četvrtoj decenijiživota, čak 14 (9,5%) od ukupnog broja ispitanika, odnosno 18% odispitanika ženskog pola. Metastaze čine 104 (71%) svih fokalnih lezija jetre.U većini slučajeva radilo se o metastazama karcinoma dojke. Iako najčešćeimaju tipičnu ultrazvučnu prezentaciju, metastaze u jetri mogu da daju širokspektar različitih ultrazvučnih slikaZaključak. Najčešće fokalne promjene u jetri su metastaze adenokarcinoma.Samo 3 (2%) fokalne promjene dijagnostikovane ultrazvukom nisu potvrđenekao fokalne laparoskopskom tehnikom i patohistološkom analizom tkiva jetre.

30.06.2022. Original Scientific Articles
Voice condition assessment and the effect of rehabilitation in vocal professionals

By Mila Bunijevac, Zlatko Maksimović, Andrijana Mikić

28.06.2021. Reviews
Vitamin D and atherosclerosis

By Olivera Rašević, Maida Mulić, Maja Vuković, Vesna Lazić, Biljana Mijović, Miloš Maksimović

01.12.2012. Original Scientific Articles
Sensibility of tactile discrimination between the fingers of the dominant and non-dominant hands

By Olivera P Spasojević, Zoran Obradović, Slavko Grbić, Marinko Domuzin, Aleksandra Grbić

30.06.2022. Original Scientific Articles
Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

Introduction. Cardiac magnetic resonance imaging (CMR) is considered the reference diagnostic method for quantifying right ventricular size and function, and pulmonary regurgitation in patients with tetralogy of Fallot surgery. The aim of this paper is to confirm the importance of magnetic resonance continuous postoperative monitoring of right and left heart function parameters as a diagnostic method that provides the most precise and accurate assessment.

Methods. The prospective observational study included subjects with TOF surgery who were diagnosed with residual morphological and/or functional disorders on control postoperative echocardiographic examinations. All subjects underwent magnetic resonance imaging of the heart on a 1.5 T scanner with dedicated coils for the heart surface according to the standard protocol for a period of one year from the beginning of the study. Criteria for exclusion from the study were: significant residual pulmonary stenosis, condition after pulmonary valve replacement, existence of residual shunt lesions, contraindications for cardiac magnetic resonance imaging (pacemaker, ICD, claustrophobia). Depending on the time elapsed since the tetralogy of Fallot surgery, the subjects were divided into groups: more than 15 years, 11−15 years, 6−10 years, less than 5 years.

Results. The study included 131 subjects with an average age of 24.18 ± 11.57 years with complete correction of TOF. Intergroup differences in values of right ventricular enddiastolic volume, right ventricular ejection fraction, and left ventricular ejection fraction were demonstrated, but there was no statistically significant intergroup difference in values of pulmonary regurgitation fraction. The negative interaction of the right and left ventricles intensifies during the years of follow-up of patients after TOF surgery, which is especially true fifteen years after surgery.

Conclusion. CMR has the most significant role in research efforts aimed at improving the outcomes of operated patients with tetralogy of Fallot.

28.06.2021. Original Scientific Articles
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By Ivana Miljković, Amajla Topuz

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

28.06.2012. Original Scientific Articles
Učešće medicinskih sestara u rješavanju akutnih komplikacija dijabetesa

By Mirjana Stamenović, Ljiljana Milović, Natalija Hadživuković, Jelena Pavlović, Sandra Joković

28.06.2014. Original Scientific Articles
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By Milan Kulić, Vesna Despotovic, Joana Maric Burmazovic, Snežana Medinica, Milan Novaković, Dragan Jovanović

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