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Pre-existing arterial microcalcification and arteriovenous fistula failure

By
Nenad Petković ,
Nenad Petković
Contact Nenad Petković

Fresenius Medical Care Dialysis Center Šamac, University clinical center of Republika Srpska , Banja Luka , Bosnia and Herzegovina

Radoslav Gajanin ,
Radoslav Gajanin

Department of Pathology, University clinical center of Republika Srpska , Banja Luka , Bosnia and Herzegovina

Ljubica Djukanović
Ljubica Djukanović

School of Medicine, University of Belgrade , Belgrade , Serbia

Abstract

Arterial microcalcification is common in patients with chronic kidney disease (CKD) and presents a significant predictor of both general and cardiovascularmortality. The study involved 22 patients (14 males, aged 60.5± 12.1) with chronic kidney disease (eGFR 11.9 ± 2.3 ml/min/1.73m2) undergoing their first AVF surgery. Radial artery specimens obtained from all patients during AVF creation were fixed and stained with hematoxylin and eosin for semiquantitative calcium quantification. Arterial microcalcification wasfound in ten (40.9%) patients. During 30 months after AVF surgery nine patients died, seven with a functioning AVF. Among these nine patients arterial microcalcification was found in five (p = 0.16). During the follow-up period unassisted AVF failure occurred in four (18.2%) patients, one of whom had arterial microcalcification (p=0.47). 

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