Introduction. Epulis is a change in gingival tissue that occurs under the influence of chronic irritation. Histologically, there are several different types of epulis. Fibrous epulis is benign tumor of gingiva that most often occurs in interdental papilla area as a result of local irritation (inadequate restorative fillings, carious teeth, subgingi...

By Marina Radanović, Slavoljub Tomić, Tanja Ivanović, Ana Cicmil, Jovana Hrisa Samardžija, Srdjan Radanović, Jelena Lečić

Introduction. Breast cancer (BC) is the most frequent type of malignancy and the leading cause of cancer related death among women worldwide. BC is exceptionally heterogeneous disease and therefore distinct treatment modalities are necessary to address these differences. The aim of our study was to investigate the impact of TP53 and PTEN tumor supp...

By Nikola Tanić, Tatjana Dramićanin, Nejla Ademović, Tijana Tomić, Blagoje Murganić, Zorka Milovanović, Milica Nedeljković, Nasta Tanić

Autophagy is a dynamic process, conserved in all eukaryotes. It is responsible for the degradation of cytoplasmic content. Autophagy is crucial in cell survival and cell death. It plays a significant role in the cell response to stress, nutrient deficiencies, embryonic development, tumor suppression, response to pathogens and aging. The process of ...

By Nikolina Elez-Burnjaković, Lejla Pojskić, Sanin Haverić, Ajla Smajlović

Introduction. The inflammatory mediators play a central role in the pathogenesis of the inflammatory process of the middle ear and cholesteatoma from the aspect of initiating and maintaining the inflammatory response to infection and lesion. The aim of the study was to examine if the presence of acquired cholesteatoma could predict pathomorphologic...

By Predrag Špirić, Mirjana Gnjatić

Introduction. Larynx carcinoma is one of the most common malignant tumors of the upper aerodigestive tract that causes the change in normal anatomical relationships in the neck, which leads to communication and social interaction disorders. The aim of the paper is to examine the impact of education on the quality of life of laryngectomized patients...

By Mila Bunijevac, Mirjana Petrović-Lazić

The human epidermal growth receptor 2 (HER2, c-erb-B2) is present in 15-20% of breast cancer at the time of diagnosis. Overexpression of HER2 receptor is associated with more aggressive form of breast cancer. Trastuzumab is a human monoclonal antibody that blocks the signaling pathways of cell proliferation by binding to the HER2 receptor. Due to t...

By Dragana Jokanović, Slađana Popović, Olivera Čančar

Introduction. Thyroglossal cyst represents the most common congenital anomaly of the neck and it occurs in approximately 7% of the overall population. It develops as a consequence of obliteration failure of ductus thyreoglossus during migration of thyroid gland in embryogenesis. It is usually diagnosed during the first decade of life by clinical ex...

By Miroslav Obrenović, Siniša Kojić, Vekoslav Mitrović, Mirjana Ćuk, Borko Davidović

Neoadjuvant approach or preoperative use of radiotherapy and chemotherapy in the treatment of locally advanced rectal cancer has led to a significant improvement in local control of the disease by reducing the percentage of local recidives. Furthermore, it has improved the quality of life since the number of sphincter sparing resections has been in...

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Uvod. Intrakranijalne aneurizme se definišu kao gigantske ako su veće od25 mm i rijetke su intrakranijalne lezije. Obično se manifestuju znacimasubarahnoidalnog krvarenja, ili kompresivnim “mass“ efektom kao tumor,epileptičnim napadom ili znacima tromboembolije. Nakon dijagnostike,kompujuterizovane tomografije i magnetne rezonanc...

By Vesna Ivanišević, Vjeran Saratlic, Sanja Marić, Radmil Marić, Branislava Ćurčić

Uvod. Meningeomi rastu sa unutrašnje strane duralnog omotača koji obavijajukičmenu moždinu, ali izvan nervnih korijenova i čine drugi najčešći intraduralniekstramedularni spinalni tumor. Uobičajeno, meningeomi su benigni,sporo rastu i mogu proći godine dok se pojave prvi neurološki simptomi.Spinalni meningeomi se javljaju najče...

By Vjeran Saratlić, Vesna Ivanišević, Sanja Marić, Radmil Marić, Branislava Ćurčić