Regardless of the fascinating progress of humanity, biotechnology and medicine, the outbreak of the global pandemic of the SARS-CoV-2 virus has shown us that we are just as vulnerable as in previous eras when communicable diseases decimated the world’s population. But the discoveries made so far at the molecular level allow us to conn...

By Nikolina Elez-Burnjaković, Ajla Smajlović, Milena Dubravac Tanasković

The vascular approach is a prerequisite for performing hemodialysis, but their "weak points" are different and frequent complications. Modern guidelines recommend native arteriovenous fistula (AVF) as the first choice of vascular approach because it is characterized by the longest survival and the least complications compared to other vascular appr...

By Nenad Lalović

Autophagy is a dynamic process, conserved in all eukaryotes. It is responsible for the degradation of cytoplasmic content. Autophagy is crucial in cell survival and cell death. It plays a significant role in the cell response to stress, nutrient deficiencies, embryonic development, tumor suppression, response to pathogens and aging. The process of ...

By Nikolina Elez-Burnjaković, Lejla Pojskić, Sanin Haverić, Ajla Smajlović

There is a daily increase in the number of patients with malignant diseases, but with the advances in modern oncology research, the number of survivors treated with malignant diseases is becoming larger and larger. The survival rate after completing oncology therapy is increasing on a daily basis, so that malignant diseases belonging to the categor...

By Srđan Popović

In a joint publication with Alfred Russell Wallace, Charles Darwin presented the theory which stated that all life forms were developed by natural selection in which the fight for survival had the effect similar to artificial intelligence applied to selective breeding. Despite a coincidence of views concerning the origin of life, these two scientis...

By Đorđe Petronić, Igor Vujović

Progress in diagnosis and treatment has led to a significant improvement in the fate of children born with tetralogy of Fallot, with the perioperative mortality of 2-3% and a 30-year survival rate of 90%. However, the majority of these patients have residual postoperative morphological and hemodynamic disorders, as well as heart rhythm disorders, p...

By Biljana Milinković, Dejan Bokonjić, Verica Prodanović

Surgical treatment of locally advanced gastrointestinal cancer alone does not exhibit satisfactory local disease control and survival rate. The advantage of using radio and chemotherapy at this stage is to reduce the likelihood of developing local recurrence with an extension of survival time, while the disadvantages are the increase in postoperati...

By Ljiljana Vasić

The human epidermal growth receptor 2 (HER2, c-erb-B2) is present in 15-20% of breast cancer at the time of diagnosis. Overexpression of HER2 receptor is associated with more aggressive form of breast cancer. Trastuzumab is a human monoclonal antibody that blocks the signaling pathways of cell proliferation by binding to the HER2 receptor. Due to t...

By Dragana Jokanović, Slađana Popović, Olivera Čančar

Introduction. There has been a progressive increase in the frequency of colorectal carcinoma for the last twenty years. In order for a doctor to estimate the life expectancy and/or the treatment of these patients, oncology makes use of prognostic and predictive factors. They are divided into: clinicosurgical, pathohistological and immunohistochemic...

By Siniša Maksimović, Branislava Jakovljević, Zdenka Gojković, Zlatko Maksimović

Neoadjuvant approach or preoperative use of radiotherapy and chemotherapy in the treatment of locally advanced rectal cancer has led to a significant improvement in local control of the disease by reducing the percentage of local recidives. Furthermore, it has improved the quality of life since the number of sphincter sparing resections has been in...

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