Introduction. Multiparametric magnetic resonance mammography (mMRM) has an important role in detection, evaluation and follow-up of breast lesions. The aim of this study was to explore whether imaging parameters, in particular ADC, can be used as a biomarker of cell proliferation in breast cancer. Methods. This cohort-study included 67 lesions in 5...

By Jelena Marić, Jasmina Boban, Tatjana Ivković-Kapicl, Dragana Djilas, Viktorija Vučaj-Ćirilović, Dragana Bogdanović-Stojanović

Cancer-related cognitive dysfunction is an important clinical probem that can interfere with the daily functioning, work productivity, childcare, and other responsibilities of women with a history of breast cancer. Risks of cancer-related cognitive impairment include cancer and cancer treatment, as well as patient-related vulnerabilities. There is ...

By Gorica Vuksanović, Jelena Marić, Olivera Kalajdžić, Ivana Zečević, Sandra Matovic, Siniša Ristić

Introduction. Breast cancer (BC) is the most frequent type of malignancy and the leading cause of cancer related death among women worldwide. BC is exceptionally heterogeneous disease and therefore distinct treatment modalities are necessary to address these differences. The aim of our study was to investigate the impact of TP53 and PTEN tumor supp...

By Nikola Tanić, Tatjana Dramićanin, Nejla Ademović, Tijana Tomić, Blagoje Murganić, Zorka Milovanović, Milica Nedeljković, Nasta Tanić

Autophagy is a dynamic process, conserved in all eukaryotes. It is responsible for the degradation of cytoplasmic content. Autophagy is crucial in cell survival and cell death. It plays a significant role in the cell response to stress, nutrient deficiencies, embryonic development, tumor suppression, response to pathogens and aging. The process of ...

By Nikolina Elez-Burnjaković, Lejla Pojskić, Sanin Haverić, Ajla Smajlović

Introduction. Obesity is becoming a global urgent issue that is considered a health problem in developed and developing countries. Obesity is a major risk factor for many non-communicable diseases such as cardiovascular diseases, type 2 diabetes mellitus (DM2), hypertension, coronary heart disease, or certain types of cancer. Physical activity is c...

By Miloš Purković, Danka Vukašinović, Una Radak

There is a daily increase in the number of patients with malignant diseases, but with the advances in modern oncology research, the number of survivors treated with malignant diseases is becoming larger and larger. The survival rate after completing oncology therapy is increasing on a daily basis, so that malignant diseases belonging to the categor...

By Srđan Popović

Surgical treatment of locally advanced gastrointestinal cancer alone does not exhibit satisfactory local disease control and survival rate. The advantage of using radio and chemotherapy at this stage is to reduce the likelihood of developing local recurrence with an extension of survival time, while the disadvantages are the increase in postoperati...

By Ljiljana Vasić

The human epidermal growth receptor 2 (HER2, c-erb-B2) is present in 15-20% of breast cancer at the time of diagnosis. Overexpression of HER2 receptor is associated with more aggressive form of breast cancer. Trastuzumab is a human monoclonal antibody that blocks the signaling pathways of cell proliferation by binding to the HER2 receptor. Due to t...

By Dragana Jokanović, Slađana Popović, Olivera Čančar

Carcinoma of the middle ear is a rare otologic disease. The development of malignancy is most commonly associated with chronic inflammation of the middle ear, although the mechanisms of this development have not been clarified yet. The symptoms of the carcinoma are not always specific and the cancer is frequently diagnosed in its advanced stage. Ea...

By Dragoslava Đerić

Introduction. There has been a progressive increase in the frequency of colorectal carcinoma for the last twenty years. In order for a doctor to estimate the life expectancy and/or the treatment of these patients, oncology makes use of prognostic and predictive factors. They are divided into: clinicosurgical, pathohistological and immunohistochemic...

By Siniša Maksimović, Branislava Jakovljević, Zdenka Gojković, Zlatko Maksimović