Introduction. Gastric adenocarcinoma is a major cause of global cancer mortality. The HER2 receptor plays a critical role in cell proliferation and survival and is overexpressed or amplified in a subset of gastric cancers, particularly of the intestinal type. The objective of this study was to evaluate HER2 protein expression and gene amplification...

By Mirjana Ćuk, Radoslav Gajanin, Svjetlana Kulić, Milena Vasić Milanović

Introduction. Tungsten disulfide (WS₂) nanoparticles possess unique physicochemical properties, making them promising candidates for biomedical applications. While previous studies have demonstrated the in vitro biocompatibility of WS₂ in various cell lines, their effects on neutrophil function remain unexplored.Methods. Human neutrophils were isol...

By Snežana Zečević, Darinka Popović, Sara Rakočević, Vanja Mališ, Ljiljana Jojić, Marija Drakul, Dušan Mihajlović, Miodrag Čolić

Modern nursing studies the psychological characteristics of patients, manifested in both healthy and ill individuals under care, as well as those traits essential for the nurse’s professional practice, with empathy standing out in particular. Empathic sensitivity is a sign of an individual’s general level of sensitivity, and that sensit...

By Valentina Šćekić, Milena Bulatović

Metformin (dimethyl biguanide) is an oral antidiabetic agent and one of the most commonly prescribed medications in endocrinology. In addition to its primary use in treating type 2 diabetes, it has a broader range of indications and is generally considered to have a favorable safety profile. The most common side effects are gastrointestinal, includ...

By Goran Bokan, Zoran Mavija

Inguinal hernia represents a significant global health challenge, with more than 20 million operations performed annually. This paper provides a comprehensive review of contemporary practice, critically analyzing the evolution of treatment from the concept of the “gold standard” toward a personalized approach. The study integrates the l...

By Rade Miletić, Nenad Lalović, Siniša Kojić

Introduction. Benign pituitary tumors are a heterogeneous group of neoplasms with varying clinical presentations depending on their hormonal activity, size, and mass effects. These tumors can cause significant morbidity due to endocrine dysfunction and compression of adjacent structures. Understanding their clinical characteristics is essential for...

By Aleksandra Marković, Tamara Dojčinović, Milena Brkić, Tamara Popović Perić

Introduction. Anticoagulants have the key role in prevention of thromboembolism including ischemic stroke, in patients with non-valvular atrial fibrillation (NVAF). The European Association of Cardiology (ESC) recommends new oral anticoagulant drugs (NOACs) as first choice therapy because of approved effectiveness and safety profile compared to vit...

By Nevena Todorović, Nataša Pilipović-Broćeta, Aleksandra Lukić, Brankica Marković, Verica Prodanović

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, was marked by a high incidence of thrombotic complications contributing to poor outcomes, particularly in hospitalized patients. Acetylsalicylic acid (ASA), known for its antiplatelet and anti-inflammatory properties, has been widely investigated for its potential role in mitigating thrombotic ...

By Verica Prodanović, Marijana Kovačević, Maksim Kovačević

Introduction. Vocal fold paralysis (VFP) is characterized by the immobility of one or both vocal folds, leading to impaired phonation, which significantly affects the patient’s professional and social activities. The aim of this study was to examine the importance of the Voice-related Quality of Life (V-RQOL) questionnaire in assessing the qu...

By Mirjana Gnjatić, Dalibor Vranješ, Daliborka Tadić, Zorica Novaković

Introduction. Neuropathic pain (NP) is presented with a variety of symptoms, including “positive” (e.g., spontaneous pain, paresthesia, dysesthesia, allodynia, hyperalgesia, tingling, burning) and “negative” (e.g., numbness and loss of sensation) features. The most common causes are diabetic peripheral neuropathy (DPN) and c...

By Zoran Vukojević, Aleksandra Dominović Kovačević, Sanja Grgić, Daliborka Tadić, Srdjan Mavija