Metformin (dimethyl biguanide) is an oral antidiabetic agent and one of the most commonly prescribed medications in endocrinology. In addition to its primary use in treating type 2 diabetes, it has a broader range of indications and is generally considered to have a favorable safety profile. The most common side effects are gastrointestinal, includ...

By Goran Bokan, Zoran Mavija

Introduction. Gastric adenocarcinoma is a major cause of global cancer mortality. The HER2 receptor plays a critical role in cell proliferation and survival and is overexpressed or amplified in a subset of gastric cancers, particularly of the intestinal type. The objective of this study was to evaluate HER2 protein expression and gene amplification...

By Mirjana Ćuk, Radoslav Gajanin, Svjetlana Kulić, Milena Vasić Milanović

Modern nursing studies the psychological characteristics of patients, manifested in both healthy and ill individuals under care, as well as those traits essential for the nurse’s professional practice, with empathy standing out in particular. Empathic sensitivity is a sign of an individual’s general level of sensitivity, and that sensit...

By Valentina Šćekić, Milena Bulatović

Introduction: Thyroid dysfunction has been identified as one of the most common comorbidities in people with multiple sclerosis (pwMS). This study aimed to determine the prevalence of thyroid disease and vitamin D levels in patients with MS compared to the general population, and to assess the potential impact of thyroid status and vitamin D levels...

By Daliborka Tadić, Sanja Grgić, Aleksandra Dominović Kovačević, Zoran Vukojević, Gabrijela Malešević, Valentina Soldat Stankovic

Inguinal hernia represents a significant global health challenge, with more than 20 million operations performed annually. This paper provides a comprehensive review of contemporary practice, critically analyzing the evolution of treatment from the concept of the “gold standard” toward a personalized approach. The study integrates the l...

By Rade Miletić, Nenad Lalović, Siniša Kojić

Introduction. Modern approaches to auditory perception therapy are essential for the effective rehabilitation of individuals with hearing impairments. Speech and language therapists and hearing therapists are central to planning and delivering interventions that are grounded in current scientific knowledge and tailored to the individual needs of ea...

By Tijana Simić

Introduction. Optic nerve head drusen (ONHD) is one of the most common congenital disorder of the optic nerve with prevalence from 0,5-2% in general population. Idiopathic intracranial hypertension is a condition that occurs in children, unlike adults, regardless of gender or the presence of obesity. Both conditions in children present on the eye a...

By Željko Maraš, Tanja Kalezić, Bojan Joksimović, Radmila Balaban Djurević

Introduction. Tungsten disulfide (WS₂) nanoparticles possess unique physicochemical properties, making them promising candidates for biomedical applications. While previous studies have demonstrated the in vitro biocompatibility of WS₂ in various cell lines, their effects on neutrophil function remain unexplored.Methods. Human neutrophils were isol...

By Snežana Zečević, Darinka Popović, Sara Rakočević, Vanja Mališ, Ljiljana Jojić, Marija Drakul, Dušan Mihajlović, Miodrag Čolić

Introduction. Vocal fold paralysis (VFP) is characterized by the immobility of one or both vocal folds, leading to impaired phonation, which significantly affects the patient’s professional and social activities. The aim of this study was to examine the importance of the Voice-related Quality of Life (V-RQOL) questionnaire in assessing the qu...

By Mirjana Gnjatić, Dalibor Vranješ, Daliborka Tadić, Zorica Novaković

Introduction. Neuropathic pain (NP) is presented with a variety of symptoms, including “positive” (e.g., spontaneous pain, paresthesia, dysesthesia, allodynia, hyperalgesia, tingling, burning) and “negative” (e.g., numbness and loss of sensation) features. The most common causes are diabetic peripheral neuropathy (DPN) and c...

By Zoran Vukojević, Aleksandra Dominović Kovačević, Sanja Grgić, Daliborka Tadić, Srdjan Mavija