Swelling of the optic nerve head due to the coexistence of idiopathic intracranial hypertension and optic nerve drusen
Introduction. Optic nerve head drusen (ONHD) is one of the most common congenital disorder of the optic nerve with prevalence from 0,5-2% in general population. Idiopathic intracranial hypertension is a condition that occurs in children, unlike adults, regardless of gender or the presence of obesity. Both conditions in children present on the eye a...
By Željko Maraš, Tanja Kalezić, Bojan Joksimović, Radmila Balaban Djurević
Metformin-associated hepatotoxicity: a literature review
Metformin (dimethyl biguanide) is an oral antidiabetic agent and one of the most commonly prescribed medications in endocrinology. In addition to its primary use in treating type 2 diabetes, it has a broader range of indications and is generally considered to have a favorable safety profile. The most common side effects are gastrointestinal, includ...
By Goran Bokan, Zoran Mavija
Contemporary management of inguinal hernia: from global epidemiology to personalized care
Inguinal hernia represents a significant global health challenge, with more than 20 million operations performed annually. This paper provides a comprehensive review of contemporary practice, critically analyzing the evolution of treatment from the concept of the “gold standard” toward a personalized approach. The study integrates the l...
By Rade Miletić, Nenad Lalović, Siniša Kojić
Familiarity of speech and language therapists and hearing therapists in Bosnia and Herzegovina with contemporary auditory perception treatment approaches
Introduction. Modern approaches to auditory perception therapy are essential for the effective rehabilitation of individuals with hearing impairments. Speech and language therapists and hearing therapists are central to planning and delivering interventions that are grounded in current scientific knowledge and tailored to the individual needs of ea...
By Tijana Simić
Thyroid Dysfunction in Patients with Multiple Sclerosis: Prevalence and Associated Risk Factors
Introduction: Thyroid dysfunction has been identified as one of the most common comorbidities in people with multiple sclerosis (pwMS). This study aimed to determine the prevalence of thyroid disease and vitamin D levels in patients with MS compared to the general population, and to assess the potential impact of thyroid status and vitamin D levels...
By Daliborka Tadić, Sanja Grgić, Aleksandra Dominović Kovačević, Zoran Vukojević, Gabrijela Malešević, Valentina Soldat Stankovic
Early and long-term outcomes after coronary artery bypass grafting using saphenous vein grafts
Introduction. Coronary Artery Bypass Grafting (CABG) remains the cornerstone of surgical myocardial revascularization. Despite major technical refinements and the increasing use of arterial conduits, saphenous vein grafts (SVGs) continue to play a vital role but remain vulnerable to long-term occlusion. The aim of the study was to evaluate early an...
By Andjela Božić, Aleksandar Redžek
Evolution of hospitalized COVID-19 cases with emphasis on the first pandemic year: experience from the University Clinical Center of Republic of Srpska
Introduction. Infection caused by the novel coronavirus (SARSCoV-2) emerged in 2019 in China and rapidly spread worldwide. This highly contagious virus is transmitted primarily through respiratory droplets and may lead to Severe Acute Respiratory Syndrome (SARS). The World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19) a glo...
By Nataša Janjić, Goran Bokan, Uroš Kalajdžić, Antonija Verhaz, Slavica Zeljković, Zoran Mavija
The prognostic significance of HER2 in gastric adenocarcinoma
Introduction. Gastric adenocarcinoma is a major cause of global cancer mortality. The HER2 receptor plays a critical role in cell proliferation and survival and is overexpressed or amplified in a subset of gastric cancers, particularly of the intestinal type. The objective of this study was to evaluate HER2 protein expression and gene amplification...
By Mirjana Ćuk, Radoslav Gajanin, Svjetlana Kulić, Milena Vasić Milanović
Inhibition of neutrophil oxidative burst and NETosis by fullerene-like inorganic tungsten disulfide nanoparticles with preservation of cell viability
Introduction. Tungsten disulfide (WS₂) nanoparticles possess unique physicochemical properties, making them promising candidates for biomedical applications. While previous studies have demonstrated the in vitro biocompatibility of WS₂ in various cell lines, their effects on neutrophil function remain unexplored.Methods. Human neutrophils were isol...
By Snežana Zečević, Darinka Popović, Sara Rakočević, Vanja Mališ, Ljiljana Jojić, Marija Drakul, Dušan Mihajlović, Miodrag Čolić
A culture of empathy in nursing clinical practice
Modern nursing studies the psychological characteristics of patients, manifested in both healthy and ill individuals under care, as well as those traits essential for the nurse’s professional practice, with empathy standing out in particular. Empathic sensitivity is a sign of an individual’s general level of sensitivity, and that sensit...
By Valentina Šćekić, Milena Bulatović