The human epidermal growth receptor 2 (HER2, c-erb-B2) is present in 15-20% of breast cancer at the time of diagnosis. Overexpression of HER2 receptor is associated with more aggressive form of breast cancer. Trastuzumab is a human monoclonal antibody that blocks the signaling pathways of cell proliferation by binding to the HER2 receptor. Due to t...

By Dragana Jokanović, Slađana Popović, Olivera Čančar, Nikolina Dukić, Zdenka Gojković, Nenad Lalović, Jelena Vladičić Mašić, Srdjan Mašić

Introduction. There has been a progressive increase in the frequency of colorectal carcinoma for the last twenty years. In order for a doctor to estimate the life expectancy and/or the treatment of these patients, oncology makes use of prognostic and predictive factors. They are divided into: clinicosurgical, pathohistological and immunohistochemic...

By Siniša Maksimović, Branislava Jakovljević, Zdenka Gojković, Zlatko Maksimović

Uvod. Arterijska hipertenzija predstavlja globalni zdravstveni problem ipovezana je sa nizom faktora rizika. Godinama je poznato da je česta kodgojaznih i kod bolesnika sa dijabetesom. Cilj istraživanja je bio ispitati uticajšestomjesečne dijetoterapije na koncentraciju lipida i glukoze u serumu kodgojaznih bolesnika sa hipetrenzijom liječen...

By Milena Todorović, Marina Ćuković, Vladimir Marković, Zdenka Gojković

Uvod. Histološki gradus (HG), koji označava zrelost tumora, i nuklearni gradus (NG), koji predstavlja nuklearnu morfometriju, važni su prognostički faktori karcinoma dojke. Sa progresijom tumora povezan je i vaskularni endotelijalni faktor rasta (VEGF). Cilj rada je da se korelira stepen diferenciranosti tumora sa izraženošću receptor...

By Zoran Aleksić, Brano Topić, Ivanka Rakita, Predrag Dašić, Marina Vižin, Aleksandar Guzijan, Milka Vještica, Dalibor Grahovac, Zdenka Gojković