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Metformin-associated hepatotoxicity: a literature review

By
Goran Bokan Orcid logo ,
Goran Bokan
Contact Goran Bokan

Department of Gastroenterology and Hepatology, University Clinical Centre of the Republic of Srpska , Banja Luka , Bosnia and Herzegovina

Faculty of Medicine Foča, University of East Sarajevo , Foča , Bosnia and Herzegovina

Faculty of Medicine, University of Banja Luka , Banja Luka , Bosnia and Herzegovina

Zoran Mavija
Zoran Mavija

Department of Gastroenterology and Hepatology, University Clinical Centre of the Republic of Srpska , Banja Luka , Bosnia and Herzegovina

Faculty of Medicine, University of Banja Luka , Banja Luka , Bosnia and Herzegovina

Editor: Siniša Ristić

Abstract

Metformin (dimethyl biguanide) is an oral antidiabetic agent and one of the most commonly prescribed medications in endocrinology. In addition to its primary use in treating type 2 diabetes, it has a broader range of indications and is generally considered to have a favorable safety profile. The most common side effects are gastrointestinal, including nausea, vomiting, diarrhea, abdominal pain, and bloating. Although rare, cases of severe liver injury attributed to metformin have been reported. This paper provides a review of the existing literature on metformin-induced hepatotoxicity.

Author Contributions

Conceptualization, G.B.; Data curation, G.B.; Funding acquisition, G.B.; Investigation, G.B.; Methodology, G.B.; Resources, G.B.; Software, G.B.; Visualization, G.B.; Writing – original draft, G.B.; Writing – review & editing, G.B.; Formal Analysis, Z.M.; Supervision, Z.M.; Validation, Z.M. All authors have read and agreed to the published version of the manuscript.

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Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

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