Diabetic retinopathy (DR) is a chronic microvascular complication of diabetes. Due to the dramatic increase in the number of diabetes cases, the prevalence of DR has also risen, making it the leading cause of blindness among the working-age population worldwide, despite the availability of screenings and modern therapeutic options. Risk factors for...

By Nada Avram, Biljana Mijović, Dragana Sokolović, Biljana Milinković, Verica Prodanović, Nenad Lalović, Nikolina Elez-Burnjaković

Speech is a way of communication formed by rhythmic units of syllables, words and sentences, and as such is inherent in man, the only being whose organs and psyche are trained for this process. Delayed speech is defined as a phenomenon in which a child does not start speaking on time, or there are errors in the speech pattern that are not appropria...

By Ana Lukić, Bojan Joksimović, Jelena Vidojević, Kristina Drašković, Aleksandar Tanović, Veljko Marić, Nenad Lalović, Vesna Krstović Spremo, Siniša Ristić

The vascular approach is a prerequisite for performing hemodialysis, but their "weak points" are different and frequent complications. Modern guidelines recommend native arteriovenous fistula (AVF) as the first choice of vascular approach because it is characterized by the longest survival and the least complications compared to other vascular appr...

By Nenad Lalović, Zlatko Maksimović, Siniša Maksimović

The human epidermal growth receptor 2 (HER2, c-erb-B2) is present in 15-20% of breast cancer at the time of diagnosis. Overexpression of HER2 receptor is associated with more aggressive form of breast cancer. Trastuzumab is a human monoclonal antibody that blocks the signaling pathways of cell proliferation by binding to the HER2 receptor. Due to t...

By Dragana Jokanović, Slađana Popović, Olivera Čančar, Nikolina Dukić, Zdenka Gojković, Nenad Lalović, Jelena Vladičić Mašić, Srdjan Mašić

Uvod. Uspješnost izvođenja vaskularnih rekonstrukcija, naročito velikihabdominalnih i torakalnih krvnih sudova, nije promijenila stavove većineonkoloških hirurga koji smatraju da je tumorska invazija vaskularnih strukturarelativna kontraindikacija za uklanjanje tumora. Cilj rada je pokazatida operacije retroperitonealnih tumora koji s...

By Đorđe Radak, Sanja Marić, Dražan Erić, Radmil Marić, Veljko Marić, Nenad Lalović, Helena Marić, Mirjana Ćuk, Vjeran Saratlic, Rade Miletić, Dalibor Potpara, Velibor Simetić, Zoran Ivković, Siniša Ristić

Uvod. Luksacija je jedna od najznačajnijih komplikacija nakon aloartroplastikekuka. Cilj ove studije je analiza učestalosti luksacija nakon aloartroplastike kuka. Metode. Analizirani su pacijenti hospitalizovani na ortopedskom odsjeku Kliničkog centra Istočno Sarajevo, Bolnice Foča u periodu od 1999. do 2007.godine. Rezultati. Tokom ovog perioda im...

By Maksim Kovačević, Milivoje Dostić, Veljko Marić, Rade Miletić, Dražan Erić, Nenad Lalović, Dalibor Potpara, Helena Marić, Marijana Kovačević, Siniša Ristić, Sanja Marić, Radmil Marić

Introduction. Extramural venous invasion (EMVI) is a significant predictive factor of the prognosis for patients with colorectal carcinoma and it is directly connected with the relapse of a disease, especially with the appearance of distant metastases. Methods. The research comprises 90 patients with colorectal cancer. Representative samples of tum...

By Mirjana Ćuk, Slavica Knežević Ušaj, Ištvan Klem, Radoslav Gajanin, Danijela Batinić Škipina, Radmil Marić, Sanja Marić, Nenad Lalović, Nikolina Dukić

Introduction. The Bcl-2 gene codes an oncoprotein, inhibits a programmed cell death or apoptosis and it plays a very important role in colorectal cancerogenesis. The aim of our study is to determine Bcl-2 expression in colorectal carcinomas in relation with the stage of disease, histology of tumor type, localization and macroscopic growth pattern. ...

By Danijela Batinić Škipina, Slavica Knežević Ušaj, Dragana Zec, Mirjana Ćuk, Snežana Božanić, Nenad Lalović