×
Home Current Archive Editorial board
News Contact

30.06.2022.

Original Scientific Articles

Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

Read the full article

Publishing collaboration

info

Edited by:

Prof. Siniša Ristić MD, PhD

Vol 16, No 1 (2025):

Biomedicinska istraživanja

Published: 06.02.2025.

See all
03.09.2025. Reviews Online First
A culture of empathy in nursing clinical practice

By Valentina Šćekić, Milena Bulatović

Modern nursing studies the psychological characteristics of patients, manifested in both healthy and ill individuals under care, as well as those traits essential for the nurse’s professional practice, with empathy standing out in particular. Empathic sensitivity is a sign of an individual’s general level of sensitivity, and that sensitivity depends on a person’s innate characteristics. The ability to feel empathy is of particular importance in professions where contact with another person plays a fundamental role. In recent years, enough documents have been found that use the concept of empathy in nursing care, which can have beneficial effects on patient recovery. Empathy is ability to understand attitudes, behavior and feelings of another person and also ability to express that understanding. Empathy is a key element of medical practice and is imperative to establishing interpersonal relationships. The aim of this review is to examine the importance of empathy in the daily work of healthcare professionals through a synthesis of existing literature. Since the nursing profession has always been based on caring for people in their most difficult, stressful and often uncertain situations, it is not difficult to conclude why exactly empathy is perceived as one of the most important qualities of the nurse. Empathy contributes to a strong connection between people, and is based on love for people.

03.09.2025. Original Scientific Articles Online First
Inhibition of neutrophil oxidative burst and NETosis by fullerene-like inorganic tungsten disulfide nanoparticles with preservation of cell viability

By Snežana Zečević, Darinka Popović, Sara Rakočević, Vanja Mališ, Ljiljana Jojić, Marija Drakul, Dušan Mihajlović, Miodrag Čolić

Introduction. Tungsten disulfide (WS₂) nanoparticles possess unique physicochemical properties, making them promising candidates for biomedical applications. While previous studies have demonstrated the in vitro biocompatibility of WS₂ in various cell lines, their effects on neutrophil function remain unexplored.
Methods. Human neutrophils were isolated via dextran sedimentation and exposed to increasing concentrations of in organic fullerene-like WS₂ (IF-WS₂) (12.5–200 µg/mL). After incubation, cells were stimulated with phorbol 12-myristate 13-acetate (PMA), calcium ionophore (CaI), or N-formylmethionyl-leucyl-phenylalanine (fMLP). Cell viability was assessed by 
flow cytometry, reactive oxygen species (ROS) production was measured using luminol-based chemiluminescence, and neutrophil extracellular trap (NET) formation was quantified using Sytox Green fluorescence.
Results. IF-WS₂ had no significant effect on neutrophil viability at any tested concentration. However, ROS production was in hibited in a concentration-dependent manner, especially under PMA stimulation. IF-WS₂ also significantly reduced both spontaneous and stimulus-induced NETosis.  
Conclusion. IF-WS₂ nanoparticles attenuate key neutrophil functions, including oxidative burst and NETosis, even at low concentrations. These findings suggest their potential utility as immunomodulatory agents in inflammatory and autoimmune 
diseases.

17.07.2025. Original Scientific Articles Online First
The prognostic significance of HER2 in gastric adenocarcinoma

By Mirjana Ćuk, Radoslav Gajanin, Svjetlana Kulić, Milena Vasić Milanović

Introduction. Gastric adenocarcinoma is a major cause of global cancer mortality. The HER2 receptor plays a critical role in cell proliferation and survival and is overexpressed or amplified in a subset of gastric cancers, particularly of the intestinal type. The objective of this study was to evaluate HER2 protein expression and gene amplification in gastric adenocarcinoma and determine diagnostic concordance between immunohistochemistry (IHC), chromogenic 
in situ hybridization (CISH), and fluorescence in situ hybridization (FISH) methods.
Methods. This retrospective study analyzed 96 patients with histologically confirmed gastric adenocarcinoma who underwent radical surgery (2006–2014). HER2 expression was assessed using IHC and scored according to Hofmann’s system. All tumors with 2+ or 3+ scores were further analyzed for HER2 gene amplification using CISH and FISH. Concordance was evaluated using Cohen’s kappa coefficient.
Results. HER2 expression was negative (score 0 and 1+) in 76.1% of cases, equivocal (2+) in 10.4%, and positive (3+) in 13.5%. All patients with a 3+ score showed HER2 gene amplification using both CISH and FISH. In the 2+ group, amplification was detected in 30% (CISH) and 50% (FISH). Concordance between CISH and FISH was high (κ = 0.78, p < 0.001). HER2 positivity correlated significantly with the intestinal type and was associated with poorer survival, particularly in early-stage tumors.
Conclusion. HER2 is a relevant biomarker in intestinal-type gastric adenocarcinoma. FISH is more sensitive than CISH in equivocal IHC cases. IHC score 3+ can be considered definitive, while FISH is recommended for 2+ cases to confirm gene amplification.

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

Current issue
06.02.2025. Reviews
Mental health consequences of the COVID-19 pandemic: a narrative review

By Danijela Radulović, Svetlana Radević, Srđan Mašić

06.02.2025. Case Reports
Using Cone Beam Computed Tomography in surgical orthodontic treatment of impacted maxillary canines - a case report

By Jelena Elez, Slavoljub Tomic, Tanja Ivanovic, Jelena Krunic

06.02.2025. Original Scientific Articles
Application of hyperthermic intraperitoneal chemotherapy at the University Clinical Center of Republic of Srpska

By Zoran G. Aleksić, Dragan Tomić, Velimir Škrbić, Nenad Jaćimović, Miroslav Popović, Sladibor Lakić

06.02.2025. Original Scientific Articles
The impact of early amplification on the social development of children with hearing loss

By Dubravka Pralica

Recent issues
See all
Most read
See all
01.12.2011. Original Scientific Articles
Dijagnostika fokalnih promjena u jetri

By Zoran Terzić, Branko Brmbolić, Miloš Korać, Boban Đorđević, Dragica Terzić, Bogdanka Andrić, Siniša Ristić

Uvod. Patološki procesi u jetri mogu biti difuznog karaktera (zapaljenski,metaboličke bolesti, hematološke bolesti, toksične bolesti) i fokalne (zapaljenske,parazitarne i tumorske). Cilj rada je prikaz fokalnih promjena u jetrinomparenhimu nakon ultrazvučne, laparaskopske i patohistološke dijagnostike.Metode. Retrospektivno-prospektivnim ispitivanjem je obuhvaćeno 147punoljetnih pacijenata oba pola. Fokalne promjene jetrinog tkiva su sagledaneultrazvučnom, laparoskopskom i patohistološkom dijagnostikom.Rezultati. Osnovne karakteristike ispitanika: muškaraca 71 i žena 76 sanajvećim brojem pacijenata (102 - 70%) životne dobi između 40 i 70 godina,sa ravnomjernom distribucijom za svakih deset godina starosti. Međutim,neobično je veliki broj pacijenata ženskog pola registrovan u četvrtoj decenijiživota, čak 14 (9,5%) od ukupnog broja ispitanika, odnosno 18% odispitanika ženskog pola. Metastaze čine 104 (71%) svih fokalnih lezija jetre.U većini slučajeva radilo se o metastazama karcinoma dojke. Iako najčešćeimaju tipičnu ultrazvučnu prezentaciju, metastaze u jetri mogu da daju širokspektar različitih ultrazvučnih slikaZaključak. Najčešće fokalne promjene u jetri su metastaze adenokarcinoma.Samo 3 (2%) fokalne promjene dijagnostikovane ultrazvukom nisu potvrđenekao fokalne laparoskopskom tehnikom i patohistološkom analizom tkiva jetre.

30.06.2022. Original Scientific Articles
Voice condition assessment and the effect of rehabilitation in vocal professionals

By Mila Bunijevac, Zlatko Maksimović, Andrijana Mikić

01.12.2012. Original Scientific Articles
Sensibility of tactile discrimination between the fingers of the dominant and non-dominant hands

By Olivera P Spasojević, Zoran Obradović, Slavko Grbić, Marinko Domuzin, Aleksandra Grbić

28.06.2021. Reviews
Vitamin D and atherosclerosis

By Olivera Rašević, Maida Mulić, Maja Vuković, Vesna Lazić, Biljana Mijović, Miloš Maksimović

30.06.2022. Original Scientific Articles
Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

Introduction. Cardiac magnetic resonance imaging (CMR) is considered the reference diagnostic method for quantifying right ventricular size and function, and pulmonary regurgitation in patients with tetralogy of Fallot surgery. The aim of this paper is to confirm the importance of magnetic resonance continuous postoperative monitoring of right and left heart function parameters as a diagnostic method that provides the most precise and accurate assessment.

Methods. The prospective observational study included subjects with TOF surgery who were diagnosed with residual morphological and/or functional disorders on control postoperative echocardiographic examinations. All subjects underwent magnetic resonance imaging of the heart on a 1.5 T scanner with dedicated coils for the heart surface according to the standard protocol for a period of one year from the beginning of the study. Criteria for exclusion from the study were: significant residual pulmonary stenosis, condition after pulmonary valve replacement, existence of residual shunt lesions, contraindications for cardiac magnetic resonance imaging (pacemaker, ICD, claustrophobia). Depending on the time elapsed since the tetralogy of Fallot surgery, the subjects were divided into groups: more than 15 years, 11−15 years, 6−10 years, less than 5 years.

Results. The study included 131 subjects with an average age of 24.18 ± 11.57 years with complete correction of TOF. Intergroup differences in values of right ventricular enddiastolic volume, right ventricular ejection fraction, and left ventricular ejection fraction were demonstrated, but there was no statistically significant intergroup difference in values of pulmonary regurgitation fraction. The negative interaction of the right and left ventricles intensifies during the years of follow-up of patients after TOF surgery, which is especially true fifteen years after surgery.

Conclusion. CMR has the most significant role in research efforts aimed at improving the outcomes of operated patients with tetralogy of Fallot.

28.06.2021. Original Scientific Articles
The knowledge of nurses about prevention of infections caused by the bacteria Clostridium difficile

By Ivana Miljković, Amajla Topuz

28.12.2020. Reviews
Importance of documentation in nursing practice

By Amajla Topuz, Ivana Miljković

01.12.2015. Case Reports
Faktori koji utiču na ishod liječenja sindroma kaude ekvine

By Zorislava Bajić, Milada Nalesnik, Tatjana Boškić, Biljana Jovanović, Tatjana Bućma

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

Partners