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30.06.2022.

Original Scientific Articles

Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

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Edited by:

Prof. Siniša Ristić MD, PhD

Vol 15, No 1 (2024):

Biomedicinska istraživanja

Published: 18.11.2024.

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04.11.2024. Original Scientific Articles Online First
The effect of glucoregulation on hearing loss in patients with diabetes mellitus type 2

By Mirjana Gnjatić, Dalibor Vranješ, Tamara Dojčinović, Jelena Malinović Pančić, Boris Dojčinović

Introduction. Hyperglycemia causes the well-known microvascular complications of diabetes mellitus (DM) such as diabetic retinopathy, polyneuropathy and nephropathy, but it can also affect the inner ear, and hearing loss (HL) can be considered as one of the microvascular complications. The aim of the study was to evaluate association between HL and values of glycated hemoglobin A1c (HbA1c) in patients with diabetes mellitus type 2 (DMT2).
Methods. In this retrospective-observational cross sectional study, we included 80 patients divided into two groups: experimental group consisting of 40 patients with DMT2 and control group consisting of 40 patients who were not previously diagnosed with DM. Data were retrieved from electronic medical records of patients treated in outpatient clinic of the Ear, Nose and Throat Department, University clinical center of Republic of Srpska (UCC RS) from 2023 to 2024. 
Results. Out of 40 patients from experimental group, 15 were males (37.5%) and 25 were females (62.5%). Regarding glycoregulation patterns in experimental group, patients were stratified into three subgroups: HbA1c < 7% (N 17; 42.5%), HbA1c-9% (N 17; 42.5%) and HbA1c > 9% (N 6; 15%). In the experimental group, a significant (p<0.000) greater number of patients had HL, and significant greater number of patients had bilateral HL (N 32; 80%, p<0.05) with predominantly pronounced sensorineural HL (N 36; 90%, p<0.05).
Conclusion. Patients with DMT2 had a higher incidence of HL compared to controls. The sensorineural type of HL showed a significantly high prevalence among patients with DMT2. HbA1c levels may be a potentially significant predictor of HL in DMT2.

09.10.2024. Original Scientific Articles Online First
Lyme neuroborreliosis in adults - epidemiology data and clinical findings

By Tatjana Roganović, Janja Bojanić, Biljana Mijović, Dragan Kasagić, Antonija Verhaz, Dragana Roganović

Introduction. Lyme neuroborreliosis (LNB) can manifest during the early and late stages of Lyme disease (LD). The aim of this study is to determine epidemiology and clinical findings in patients with LNB. 
Methods. The research was conducted in Banja Luka at the University Clinical Center of Republic of Srpska (UCC RS) during a four-year period from 10/2017 to 10/2021. The research included 51 patients admitted to the hospital with some neurological symptoms that could lead to the LNB diagnosis. Patients had lumbar puncture with cytochemical analysis of cerebrospinal fluid (CSF), ELISA anti-Borrelia IgM/IgG in serum and CSF, Immunoblot anti-Borrelia IgM/IgG in serum, and other documentation about epidemiology and clinical findings in LNB.  
Results. A statistically significant (p=0.017) higher proportion of female patients was observed. Most patients were between 50 and 60 years old. Most of them were retirees (31.37%), farmers, medical technicians followed with forestry workers, students etc. Most of examinees did not have information on previous tick bite (64.71%). The largest number (72.55%) did not have data on previous skin changes. The largest number of neurological symptoms at admission related to the feeling of tingling and weakness in the extremities, headache, dizziness and some ophthalmological symptoms. Patients also suffered from consciousness and speech disorder, anxiety, paresis n.VII. The largest number of examinees had some neurological symptoms up to three months prior the admission to the hospital.  
Conclusion. Symptoms of LNB can be quite non-specific or possibly even mimic other neurological diseases. Involvement 
of peripheral nervous system is dominant in adult patients. It is necessary to work on early diagnosis of LD and it is mandatory to report it to the national epidemiological service. 

20.09.2024. Original Scientific Articles Online First
Impact of the COVID-19 pandemic on the antimicrobial resistance at the General Hospital level in Republic of Srpska, Bosnia and Herzegovina

By Nasta Manojlović, Biljana Mijović, Zlatko Maksimović, Dragana Sokolović, Sanda Lazić, Ljubica Bojanić, Dragana Drakul, Nenad Lalović, Marija Lukić, Bojan Joksimović

Introduction. Hyperglycemia causes the well-known microvascular complications of diabetes mellitus (DM) such as diabetic retinopathy, polyneuropathy and nephropathy, but it can also affect the inner ear, and hearing loss (HL) can be considered as one of the microvascular complications. The aim of the study was to evaluate association between HL and values of glycated hemoglobin A1c (HbA1c) in patients with diabetes mellitus type 2 (DMT2).
Methods. In this retrospective-observational cross sectional study, we included 80 patients divided into two groups: experimental group consisting of 40 patients with DMT2 and control group consisting of 40 patients who were not previously diagnosed with DM. Data were retrieved from electronic medical records of patients treated in outpatient clinic of the Ear, Nose and Throat Department, University clinical center of Republic of Srpska (UCC RS) from 2023 to 2024. 
Results. Out of 40 patients from experimental group, 15 were males (37.5%) and 25 were females (62.5%). Regarding glycoregulation patterns in experimental group, patients were stratified into three subgroups: HbA1c < 7% (N 17; 42.5%), HbA1c-9% (N 17; 42.5%) and HbA1c > 9% (N 6; 15%). In the experimental group, a significant (p<0.000) greater number of patients had HL, and significant greater number of patients had bilateral HL (N 32; 80%, p<0.05) with predominantly pronounced sensorineural HL (N 36; 90%, p<0.05).
Conclusion. Patients with DMT2 had a higher incidence of HL compared to controls. The sensorineural type of HL showed a significantly high prevalence among patients with DMT2. HbA1c levels may be a potentially significant predictor of HL in DMT2.

18.09.2024. Original Scientific Articles Online First
Test anxiety as a risk factor for use of psychoactive compounds in medical students

By Branislava Ćurčić, Dragana Sokolović, Milica Radanović, Dragana Pavlović, Marija Bjeletić, Djordje Vuković, Dragana Drakul

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

Current issue
18.11.2024. Original Scientific Articles
Relationship between perceived stress and levels of blood pressure: single center study

By Milena Guslov, Marko Filipović, Danijela Tasić, Sladjana Božović Ogarević, Biljana Despotović, Zorana Bogićević, Milan Arsić, Svetislav Pelemiš, Maša Petrović, Zlatko Maksimović, Nebojša Tasić

18.11.2024. Reviews
The transformative power of AI and wearables in the global prevention of cardiovascular disease

By Maša Petrović, Svetislav Pelemiš, Ana Dimitrijević, Srdjan Babić, Sulin Bulatović, Nebojša Tasić, Danijela Tasić, Zorana Bogićević, Sladjana Božović-Ogarčević, Milan Arsić, Marko Filipović, Milena Guslov, Branko Lozuk, Zlatko Maksimović, Milovan Bojić

Recent issues
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01.12.2011. Original Scientific Articles
Dijagnostika fokalnih promjena u jetri

By Zoran Terzić, Branko Brmbolić, Miloš Korać, Boban Đorđević, Dragica Terzić, Bogdanka Andrić, Siniša Ristić

Uvod. Patološki procesi u jetri mogu biti difuznog karaktera (zapaljenski,metaboličke bolesti, hematološke bolesti, toksične bolesti) i fokalne (zapaljenske,parazitarne i tumorske). Cilj rada je prikaz fokalnih promjena u jetrinomparenhimu nakon ultrazvučne, laparaskopske i patohistološke dijagnostike.Metode. Retrospektivno-prospektivnim ispitivanjem je obuhvaćeno 147punoljetnih pacijenata oba pola. Fokalne promjene jetrinog tkiva su sagledaneultrazvučnom, laparoskopskom i patohistološkom dijagnostikom.Rezultati. Osnovne karakteristike ispitanika: muškaraca 71 i žena 76 sanajvećim brojem pacijenata (102 - 70%) životne dobi između 40 i 70 godina,sa ravnomjernom distribucijom za svakih deset godina starosti. Međutim,neobično je veliki broj pacijenata ženskog pola registrovan u četvrtoj decenijiživota, čak 14 (9,5%) od ukupnog broja ispitanika, odnosno 18% odispitanika ženskog pola. Metastaze čine 104 (71%) svih fokalnih lezija jetre.U većini slučajeva radilo se o metastazama karcinoma dojke. Iako najčešćeimaju tipičnu ultrazvučnu prezentaciju, metastaze u jetri mogu da daju širokspektar različitih ultrazvučnih slikaZaključak. Najčešće fokalne promjene u jetri su metastaze adenokarcinoma.Samo 3 (2%) fokalne promjene dijagnostikovane ultrazvukom nisu potvrđenekao fokalne laparoskopskom tehnikom i patohistološkom analizom tkiva jetre.

30.06.2022. Original Scientific Articles
Voice condition assessment and the effect of rehabilitation in vocal professionals

By Mila Bunijevac, Zlatko Maksimović, Andrijana Mikić

28.06.2021. Reviews
Vitamin D and atherosclerosis

By Olivera Rašević, Maida Mulić, Maja Vuković, Vesna Lazić, Biljana Mijović, Miloš Maksimović

01.12.2012. Original Scientific Articles
Sensibility of tactile discrimination between the fingers of the dominant and non-dominant hands

By Olivera P Spasojević, Zoran Obradović, Slavko Grbić, Marinko Domuzin, Aleksandra Grbić

28.06.2021. Original Scientific Articles
The knowledge of nurses about prevention of infections caused by the bacteria Clostridium difficile

By Ivana Miljković, Amajla Topuz

Introduction. Clostridium difficile is the leading cause of nosocomial diarrhea, associated with the use of antibiotics. The most common ways of transmitting the infection in hospitals are contaminated surfaces of the premises and the hands of medical staff. Methods. The study involved 68 nurses/technicians employed at the University Hospital Foca in the departments of surgery and internal medicine. As a research instrument, we used a specially designed questionnaire, created by the authors for the purpose of this research. Results. The research showed that 61.8% of respondents knew that hand washing with warm water and soap was considered the most effective prevention of the spread of infections, and 55.88% meant that they used chlorine-based preparations and hydrogen peroxide as the only effective disinfectant. Nurses with a work experience of less than 5 years showed better knowledge than other groups. Conclusion. The knowledge of nurses about the prevention of C. difficile infection is not at a satisfactory level, which indicates the growing need for education of nurses.

30.06.2022. Original Scientific Articles
Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

28.12.2020. Reviews
Importance of documentation in nursing practice

By Amajla Topuz, Ivana Miljković

28.06.2012. Original Scientific Articles
Učešće medicinskih sestara u rješavanju akutnih komplikacija dijabetesa

By Mirjana Stamenović, Ljiljana Milović, Natalija Hadživuković, Jelena Pavlović, Sandra Joković

Uvod. Akutne komplikacije dijabetesa predstavljaju akutno nastale metaboličkeporemećaje u čijoj osnovi leže ekstremni poremećaji nivoa glukoze u krvi.Cilj ovog istraživanja je da se ispita učestalost pojave akutnih komplikacijakod oboljelih od dijabetesa koje su nastale kao posljedica loše glikoregulacijei analizira obim i sadržaj sestrinskog rada u rješavanju tih komplikacija.Metode. Istraživanje je izvedeno u periodu septembar-oktobar 2011.godine nainternom odjeljenju u Univerzitetskoj bolnici Foča. U istraživanju su korišćenadva anonimna upitnika kojim su anketirani pacijenti koji boluju od dijabetesai medicinske sestre koje učestvuju u njihovom liječenju.Rezultati. Više od polovine pacijenata (60%) je upoznato sa komplikacijamadijabetesa, a više od dvije trećine (73%) ispitanika zna prepoznati znakehiperglikemije, dok 63% ispitanika zna da su osjećaj mučnine, gladi i klonulostiznaci hipoglikemije. Najveći dio medicinskog osoblja (71%) smatra daje najčešći uzrok komplikacija ne uzimanje terapije, zato više od dvije trećineispitanika (79%) motiviše pacijente da se pridržavaju higijensko-dijetetskogrežima i da redovno uzimaju terapiju.Zaključak. Naši rezultati ukazuju da pacijenti nisu dovoljno upoznati saakutnim komplikacijama dijabetesa, a da je znanje medicinskog osoblja nazadovoljavajućem nivou, mada može da bude još bolje. Zato je neophodnakontinuirana edukacija, kako bolesnika tako i medicinskog osoblja sa ciljemprevencije komplikacija od dijabetesa.

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