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Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
PHI Hospital „Sveti Vračevi“, Bijeljina, Bosnia and Herzegovina
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Department of Obstetrics and Gynecology, Faculty of Medicine, University of Novi Sad , Novi Sad, Serbia
Department of Obstetrics and Gynecology, Faculty of Medicine, Clinical Centre of Vojvodina, Novi Sad, Serbia
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Department of Obstetrics and Gynecology, Faculty of Medicine, Clinical Centre of Vojvodina, Novi Sad, Serbia
Introduction. A significant proportion of women globally, consti tuting 38%, are obese, among whom 24.5% reside in Europe. Obe sity elevates the risk of premature birth due to associated maternal conditions, such as preeclampsia. The objectives were to assess: variations in demographic and clinical characteristics among preg nant women across groups; the impact of obesity on the incidence of preeclampsia and preterm delivery; and the influence of obesity on newborn characteristics.
Methods. One-year prospective study included 133 pregnant wom en gestational age 11-14 gestational week (GW), divided into two groups: OB (41.35%) and CG (58.65%). The data were analyzed using IBM SPSS version 23.
Results. There is statistically significant difference in average body mass index (BMI) (22.01 ± 1.83 vs. 30.26 ± 4.52; p < 0.001) and de livery time (37.94 ± 2.05 vs. 36.87 ± 2.45; p = 0.003) between CG and OB. Obese pregnant women developed preeclampsia significantly more often than normal weight (61.82% vs. 28.21%; p < 0.001). Body mass index has significant moderate predictive ability to predict preeclampsia (AUC 0.696 (95% CI: [0.601; 0.79]). Higher BMI (OR = 1.19, [1.09; 1.29], p < 0.0001) was associated with higher rates of pre eclampsia. Overweight (OR = 2.41, [1.07; 5.43], p = 0.0335), obesity class I, II and III (OR = 20.36, [4.32; 95.99], p = 0.0001) were associated with higher rates of preeclampsia. A poor negative correlation was found between BMI and GW of pregnancy outcome (p = -0.24; r2 = 0.104; p = 0.006). Higher BMI (β = -0.14, [-0.21; -0.07], p = 0.0002) was associated with lower values of GW of pregnancy outcome.
Conclusions. Presence of obesity or overweightness in the first tri mester of pregnancy poses a significant risk factor for preeclampsia and preterm delivery.
Conceptualization, T.P., M.B. and Z.B.; Data curation, T.P., M.B. and Z.B.; Formal Analysis, T.P.; Methodology, T.P. and M.B.; Software, T.P.; Supervision, T.P., M.B. and Z.B.; Visualization, T.P.; Writing – original draft, T.P.; Project administration, M.B.; Validation, M.B. and Z.B.; Writing – review & editing, M.B. and Z.B. All authors have read and agreed to the published version of the manuscript.
No competing financial interests exist.
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