Introduction. Postoperative cognitive dysfunction (POCD) is very common in patients who are treated in intensive care units or in the surgery department after surgery. This increasingly present complication complicates and calls into question the recovery of the operated patient. We assumed that POCD was associated with blood loss in patients under...

By Dalibor P. Bošković, Sanja Marić, Marko Kovačević, Bojan Golijanin

Surgical treatment of locally advanced gastrointestinal cancer alone does not exhibit satisfactory local disease control and survival rate. The advantage of using radio and chemotherapy at this stage is to reduce the likelihood of developing local recurrence with an extension of survival time, while the disadvantages are the increase in postoperati...

By Ljiljana Vasić

Introduction. There has been a progressive increase in the frequency of colorectal carcinoma for the last twenty years. In order for a doctor to estimate the life expectancy and/or the treatment of these patients, oncology makes use of prognostic and predictive factors. They are divided into: clinicosurgical, pathohistological and immunohistochemic...

By Siniša Maksimović, Branislava Jakovljević, Zdenka Gojković, Zlatko Maksimović

Neoadjuvant approach or preoperative use of radiotherapy and chemotherapy in the treatment of locally advanced rectal cancer has led to a significant improvement in local control of the disease by reducing the percentage of local recidives. Furthermore, it has improved the quality of life since the number of sphincter sparing resections has been in...

By Ljiljana Vasić

Introduction. Extramural venous invasion (EMVI) is a significant predictive factor of the prognosis for patients with colorectal carcinoma and it is directly connected with the relapse of a disease, especially with the appearance of distant metastases. Methods. The research comprises 90 patients with colorectal cancer. Representative samples of tum...

By Mirjana Ćuk, Slavica Knežević Ušaj, Ištvan Klem, Radoslav Gajanin, Danijela Batinić Škipina, Radmil Marić, Sanja Marić, Nenad Lalović, Nikolina Dukić

Introduction. The Bcl-2 gene codes an oncoprotein, inhibits a programmed cell death or apoptosis and it plays a very important role in colorectal cancerogenesis. The aim of our study is to determine Bcl-2 expression in colorectal carcinomas in relation with the stage of disease, histology of tumor type, localization and macroscopic growth pattern. ...

By Danijela Batinić Škipina, Slavica Knežević Ušaj, Dragana Zec, Mirjana Ćuk, Snežana Božanić, Nenad Lalović