Cytotoxicity and anti-inflammatory properties of a GLP-1 receptor agonist in a model of human peripheral blood mononuclear cell culture
Introduction. GLP-1R agonists (GLP-1RAs) are a type of anti-hyperglycemic medications used for the management of type 2 diabetes mellitus (T2DM). In addition to glucose-lowering effects, GLP-1R agonists (GLP-1RAs) also provide further advantages by promoting weight loss and controlling blood pressure. Furthermore, GLP-1RAs have been reported for th...
By Marija Drakul, Vanja Mališ, Sara Rakočević, Ljiljana Kozić, Darinka Popović, Anđela Mandić, Miodrag Colic
Cellulose nanocrystals induce a dose-dependent effect on cytotoxicity and proliferative activity of human peripheral blood mononuclear cells
Introduction. Cellulose nanocrystals (CNCs) as attractive natural materials, have numerous applications in the biomedical field. Their unique biomechanical characteristics, surface chemistry, low cost and sustainable nature make them an engaging alternative to conventional materials and potentiate their use as progressive material. Therefore, it is...
By Miloš Vasiljević, Sergej Tomić, Marina Bekić, Bojan Joksimović, Dragana Vučević, Miodrag Čolić
Differentiation plasticity of human monocytes in culture
Introduction. Human monocytes are heterogeneous and plastic cell population with the ability to undergo phenotypic and functional changes as a response to a stimulus from a local microenvironment. Our aim was to determine the potential of human monocytes to differentiate into different cell populations depending on two different cytokines (IL-4 and...
By Bojan Joksimović, Sergej Tomić, Marina Bekić, Miloš Vasiljević, Dragana Vučević, Miodrag Čolić