×
Home Current Archive Editorial board
News Contact

30.06.2022.

Original Scientific Articles

Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

Read the full article

Publishing collaboration

info

Edited by:

Prof. Siniša Ristić MD, PhD

Vol 15, No 2 (2024):

Biomedicinska istraživanja

Published: 18.12.2024.

See all
17.06.2025. Original Scientific Articles Online First
The impact of early amplification on the social development of children with hearing loss

By Dubravka Pralica

Introduction. Early amplification in children with hearing impairment plays a crucial role in their socioemotional and communicative development. Timely identification and intervention are essential to support better outcomes in communication, socialization, and emotional well-being. This study aimed to examine whether children who received hearing amplification before the age of three show better socialization outcomes compared to those amplified after the age of three.
Methods. The study involved 52 parents of children, aged between 7 and 11 years with hearing impairment, who completed a specially designed Likert-type questionnaire. The questionnaire consisted of three subscales:Communication, Socialization, and Emotional Stability. The age at which amplification was provided varied: 12 children (23%) received amplification during the first year of life, 17 (33%) during the second year, 13 (25%) during the third year, and 10 children (19%) during the fourth year. In most cases (22 children, or 42%), hearing loss was detected during the second year of life.
Results. Children who received amplification before the age of three demonstrated significantly better outcomes in socialization compared to those amplified after the age of three. Additionally, better social interaction in these children was associated with stronger verbal communication skills and greater emotional stability.
Conclusion. The findings emphasize the importance of early detection and timely amplification in children with hearing impairments. Amplification provided by the age of three leads to improved socialization, communication, and emotional development, thereby enhancing the overall quality of life for affected children.

17.06.2025. Reviews Online First
Mental health consequences of the COVID-19 pandemic: a narrative review

By Danijela Radulović, Svetlana Radević, Srđan Mašić

The COVID-19 pandemic has generated a profound psychological impact across diverse populations, exposing long-standing gaps in mental health services and intensifying social inequalities. This narrative review explores the most prevalent mental health conditions associated with the pandemic including depression, anxiety, stress, and post-traumatic stress disorder (PTSD) with emphasis on population-specific vulnerabilities such as sex, age, social status, and chronic illness. Special attention is given to the bidirectional relationship between mental and physical health, the role of social support, and behavioral mediators of psychological distress. The review underscores the need for systemic, multi-level public health responses integrating mental health into pandemic preparedness, healthcare delivery, and social policy. Lessons learned from the COVID-19 crisis offer a unique opportunity to redefine mental well-being as a global public health priority.

17.06.2025. Original Scientific Articles Online First
Prescribing patterns of anticoagulants in patients with atrial fibrillation in primary care

By Nevena Todorović, Nataša Pilipović-Broćeta, Aleksandra Lukić, Brankica Marković, Verica Prodanović

Introduction. Anticoagulants have the key role in prevention of thromboembolism including ischemic stroke, in patients with non-valvular atrial fibrillation (NVAF). The European Association of Cardiology (ESC) recommends new oral anticoagulant drugs (NOACs) as first choice therapy because of approved effectiveness and safety profile compared to vitamin K antagonists (VKAs). The aim of this study was to evaluate the frequency of prescribing anticoagulants in patients with NVAF, and the compatibility of the therapy with current recommendations for stroke prevention.
Methods. Our cross-sectional study, conducted from June 2023 to June 2024, included 238 patients with NVAF registered in the Primary Health Centre Banja Luka.  Patients’ medical records were used as the data source. The CHA2DS2-VASc and HAS-BLED instruments were used for the assessment of risk of stroke and bleeding.
Results. The majority of respondents were aged 65–84. Patients ≤ 65 years have a significantly lower risk of stroke (p=0.000). According to the CHA2DS2-VASc score, 219 patients were supposed to use anticoagulant therapy, however 73.5% of patients had adequate treatment. Mostly prescribed anticoagulants were VKAs (44.1%), followed by NOACs(29.4%), while 26.5% of patients did not use anticoagulants. The majority of patients with unregulated international normalized ratio (INR) were >75 years, and those with regulated INR were 65–74 years old (p=0.03). The risk of bleeding (HAS-BLED ≥ 3) was present in 40% of patients using anticoagulants.
Conclusion. Stroke prevention in patients with NVAF and prescribing NOACs are partially aligned with clinical recommendations. Insufficient NOACs usage has been noticed, despite their approved advantages. Additional activities are needed aiming anticoagulant therapy optimization, particularly in elderly and those with high risk for stroke.

16.06.2025. Reviews Online First
The role of TP53, APC, and KRAS gene polymorphisms in the development of colorectal cancer

By Igor Gavrić, Nenad Lalović, Jovan Kulić

26.05.2025. Original Scientific Articles Online First
Evaluation of Clinical Profiles in Patients with Benign Pituitary Tumors

By Aleksandra Marković, Tamara Dojčinović, Milena Brkić, Tamara Popović Perić

19.05.2025. Original Scientific Articles Online First
Production of chemokines by mesenchymal stromal cells established from inflamed human gingiva and its modulation by lipopolysaccharide

By Marina Radanović, Miodrag Čolić

19.05.2025. Original Scientific Articles Online First
Application of hyperthermic intraperitoneal chemotherapy at the University Clinical Center of Republic of Srpska

By Zoran G. Aleksić, Dragan Tomić, Velimir Škrbić, Nenad Jaćimović, Miroslav Popović, Sladibor Lakić

16.04.2025. Original Scientific Articles Online First
Predictive influence of sociodemographic characteristics and the type of developmental disorder on children’s adaptive achievements

By Sladjana Ćalasan, Nadica Jovanović-Simić, Bojana Drljan

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

Current issue
18.09.2024. Reviews
Possibilities of violation of ethical principles in sponsored research: analysis, consequences, and prevention measures

By Jovan Kulić, Dragana Aksentijević, Ana Kostović, Dejan Krstić, Dragana Branović, Bojan Joksimović, Marija Milić, Stefan Mitić, Siniša Ristić

18.09.2024. Reviews
Anatomy of the vertebral vein

By Slobodan Malobabić

18.09.2024. Original Scientific Articles
Assessment of mental health disorders in individuals with chronic diseases during the COVID-19 pandemic

By Danijela Radulović, Srdjan Mašić, Dejan Bokonjić, Svetlana Radević, Ivana Simić Vukomanović, Biljana Mijović, Maja Vuković, Milena Dubravac Tanasković, Mirka Jojić, Jelena Vladičić Mašić, Dragan Spaić

18.09.2024. Original Scientific Articles
The effect of socio-demographic characteristics on the burnout syndrome of nurses in Republic of Srpska during the COVID-19 pandemic

By Ljubiša Kucurski, Tamara Popović, Dijana Djurić, Jelena Pavlović, Ljiljana Savić, Srdjan Živanović, Ljubinka Božić Majstorović, Sanja Tomić

18.09.2024. Original Scientific Articles
Stress in parents of children with developmental disabilities

By Andrijana Bakoč, Olivera Kalajdžić, Ranka Perućica, Ivana Zečević

Recent issues
See all
Most read
See all
01.12.2011. Original Scientific Articles
Dijagnostika fokalnih promjena u jetri

By Zoran Terzić, Branko Brmbolić, Miloš Korać, Boban Đorđević, Dragica Terzić, Bogdanka Andrić, Siniša Ristić

Uvod. Patološki procesi u jetri mogu biti difuznog karaktera (zapaljenski,metaboličke bolesti, hematološke bolesti, toksične bolesti) i fokalne (zapaljenske,parazitarne i tumorske). Cilj rada je prikaz fokalnih promjena u jetrinomparenhimu nakon ultrazvučne, laparaskopske i patohistološke dijagnostike.Metode. Retrospektivno-prospektivnim ispitivanjem je obuhvaćeno 147punoljetnih pacijenata oba pola. Fokalne promjene jetrinog tkiva su sagledaneultrazvučnom, laparoskopskom i patohistološkom dijagnostikom.Rezultati. Osnovne karakteristike ispitanika: muškaraca 71 i žena 76 sanajvećim brojem pacijenata (102 - 70%) životne dobi između 40 i 70 godina,sa ravnomjernom distribucijom za svakih deset godina starosti. Međutim,neobično je veliki broj pacijenata ženskog pola registrovan u četvrtoj decenijiživota, čak 14 (9,5%) od ukupnog broja ispitanika, odnosno 18% odispitanika ženskog pola. Metastaze čine 104 (71%) svih fokalnih lezija jetre.U većini slučajeva radilo se o metastazama karcinoma dojke. Iako najčešćeimaju tipičnu ultrazvučnu prezentaciju, metastaze u jetri mogu da daju širokspektar različitih ultrazvučnih slikaZaključak. Najčešće fokalne promjene u jetri su metastaze adenokarcinoma.Samo 3 (2%) fokalne promjene dijagnostikovane ultrazvukom nisu potvrđenekao fokalne laparoskopskom tehnikom i patohistološkom analizom tkiva jetre.

30.06.2022. Original Scientific Articles
Voice condition assessment and the effect of rehabilitation in vocal professionals

By Mila Bunijevac, Zlatko Maksimović, Andrijana Mikić

01.12.2012. Original Scientific Articles
Sensibility of tactile discrimination between the fingers of the dominant and non-dominant hands

By Olivera P Spasojević, Zoran Obradović, Slavko Grbić, Marinko Domuzin, Aleksandra Grbić

28.06.2021. Reviews
Vitamin D and atherosclerosis

By Olivera Rašević, Maida Mulić, Maja Vuković, Vesna Lazić, Biljana Mijović, Miloš Maksimović

30.06.2022. Original Scientific Articles
Magnetic resonance imaging of the heart as a method of long-term monitoring of right heart function after tetralogy of Fallot surgery

By Biljana Milinković, Jelena Milić, Dejan Bokonjić, Verica Prodanović, Bojan Joksimović, Siniša Ristić

Introduction. Cardiac magnetic resonance imaging (CMR) is considered the reference diagnostic method for quantifying right ventricular size and function, and pulmonary regurgitation in patients with tetralogy of Fallot surgery. The aim of this paper is to confirm the importance of magnetic resonance continuous postoperative monitoring of right and left heart function parameters as a diagnostic method that provides the most precise and accurate assessment.

Methods. The prospective observational study included subjects with TOF surgery who were diagnosed with residual morphological and/or functional disorders on control postoperative echocardiographic examinations. All subjects underwent magnetic resonance imaging of the heart on a 1.5 T scanner with dedicated coils for the heart surface according to the standard protocol for a period of one year from the beginning of the study. Criteria for exclusion from the study were: significant residual pulmonary stenosis, condition after pulmonary valve replacement, existence of residual shunt lesions, contraindications for cardiac magnetic resonance imaging (pacemaker, ICD, claustrophobia). Depending on the time elapsed since the tetralogy of Fallot surgery, the subjects were divided into groups: more than 15 years, 11−15 years, 6−10 years, less than 5 years.

Results. The study included 131 subjects with an average age of 24.18 ± 11.57 years with complete correction of TOF. Intergroup differences in values of right ventricular enddiastolic volume, right ventricular ejection fraction, and left ventricular ejection fraction were demonstrated, but there was no statistically significant intergroup difference in values of pulmonary regurgitation fraction. The negative interaction of the right and left ventricles intensifies during the years of follow-up of patients after TOF surgery, which is especially true fifteen years after surgery.

Conclusion. CMR has the most significant role in research efforts aimed at improving the outcomes of operated patients with tetralogy of Fallot.

28.06.2021. Original Scientific Articles
The knowledge of nurses about prevention of infections caused by the bacteria Clostridium difficile

By Ivana Miljković, Amajla Topuz

28.12.2020. Reviews
Importance of documentation in nursing practice

By Amajla Topuz, Ivana Miljković

01.12.2015. Case Reports
Faktori koji utiču na ishod liječenja sindroma kaude ekvine

By Zorislava Bajić, Milada Nalesnik, Tatjana Boškić, Biljana Jovanović, Tatjana Bućma

28.12.2019. Original Scientific Articles
Impact of elapsed time between first symptoms and diagnosis of celiac disease on psycho-physical functioning and social life of children and adolescents

By Biljana Stojanović-Jovanović, Stevan Jovanović, Biljana Vuletić

Introduction. Celiac disease is an autoimmune disease resulting from an inadequate immune response to gluten in genetically predisposed individuals as a result of consuming gluten and other related proteins present in wheat, rye, barley and oats. The only cure for this specific disease is a strict, carefully controlled and lifelong gluten-free diet. The aim of the study was to evaluate whether the elapsed time between the onset of the first symptoms and the diagnosis of celiac disease affected the psycho-physical functioning and social life of children and adolescents.

Methods. The study involved 116 respondents (39 of them were males), aged 8-18 years, who were diagnosed with celiac disease. The Documentation Sheet and the Celiac-Specific Pediatric Health-Related Instrument (CDPQOL), measuring the psycho-physical functioning and social life, were used in the study.

Results. 50% of subjects, aged ≤ 2 years, were diagnosed with celiac disease. 48.28% of them were diagnosed with the disease within three months after the symptom onset. In respondents with celiac disease, aged 8-12 years, there was no statistically significant difference between the psycho-physical functioning and social life and the elapsed time between the first symptoms and the established diagnosis. In subjects aged 13-18 years, using CDPQOL, a statistically significant difference was found in the following domains: school functioning, going out and social events, self-confidence. Furthermore, there was a statistically significant difference between total CDPQOL score and the elapsed time between the first symptoms and the established diagnosis.

Conclusion. The elapsed time between the first symptoms and the established diagnosis significantly affects the psycho-physical functioning and social life of subjects aged 13-18 years, but it does not affect the psycho-physical functioning and social life of the younger respondents. This is to confirm the importance of early diagnosis and treatment initiation.

Partners